RIP1 Polyclonal Antibody | Invitrogen PA5-20811 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RIP1 Polyclonal Antibody

catalog :

PA5-20811

quantity :

100 ug

price :

US 481.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 4b	Ngamsri K, Gamper Tsigaras J, Reutershan J, Konrad F. Fractalkine Is Linked to the Necrosome Pathway in Acute Pulmonary Inflammation. Front Med (Lausanne). 2021;8:591790 pubmed publisher
	Liang M, Sun Z, Chen X, Wang L, Wang H, Qin L, et al. E3 ligase TRIM28 promotes anti-PD-1 resistance in non-small cell lung cancer by enhancing the recruitment of myeloid-derived suppressor cells. J Exp Clin Cancer Res. 2023;42:275 pubmed publisher
	Hassanein E, Bakr A, El Shoura E, Ahmed L, Ali F. Acetovanillone augmented the cardioprotective effect of carvedilol against cadmium-induced heart injury via suppression of oxidative stress and inflammation signaling pathways. Sci Rep. 2023;13:5278 pubmed publisher
	Cho K, Na H, Jhun J, Woo J, Lee A, Lee S, et al. Lactobacillus (LA-1) and butyrate inhibit osteoarthritis by controlling autophagy and inflammatory cell death of chondrocytes. Front Immunol. 2022;13:930511 pubmed publisher
	Na H, Woo J, Kim J, Lee J, Um I, Cho K, et al. Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. PLoS ONE. 2022;17:e0270351 pubmed publisher
	Lee A, Woo J, Lee S, Na H, Cho K, Lee Y, et al. Mitochondrial Transplantation Ameliorates the Development and Progression of Osteoarthritis. Immune Netw. 2022;22:e14 pubmed publisher
	Ashour H, Hashem H, Khowailed A, Rashed L, Hassan R, Soliman A. Necrostatin-1 mitigates renal ischaemia-reperfusion injury - time dependent - via aborting the interacting protein kinase (RIPK-1)-induced inflammatory immune response. Clin Exp Pharmacol Physiol. 2022;49:501-514 pubmed publisher
	Lin P, Xue X, Zhao Z, Lu J, Xie P. Necrostatin-1, RIP1/RIP3 inhibitor, relieves transforming growth factor β-induced wound-healing process in formation of hypertrophic scars. J Cosmet Dermatol. 2021;20:2612-2618 pubmed publisher
	Amani H, Mostafavi E, Alebouyeh M, Arzaghi H, Akbarzadeh A, Pazoki Toroudi H, et al. Would Colloidal Gold Nanocarriers Present An Effective Diagnosis Or Treatment For Ischemic Stroke?. Int J Nanomedicine. 2019;14:8013-8031 pubmed publisher

product information

Product Type :

Antibody

Product Name :

RIP1 Polyclonal Antibody

Catalog # :

PA5-20811

Quantity :

100 ug

Price :

US 481.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 20 ug/mL, Immunohistochemistry: 2.5 ug/mL, Western Blot: 1 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C

Description :

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Immunogen :

A 15 amino acid peptide from near the amino terminus of human RIPK1.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 20 ug/mL, Immunohistochemistry: 2.5 ug/mL, Western Blot: 1 ug/mL

Aliases :

cell death protein RIP; D330015H01Rik; FLJ39204; OTTHUMP00000015955; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor interacting serine/threonine kinase 1; receptor-interacting protein 1; receptor-interacting protein kinase 1; receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; RIP1; RIP-1; RIP1 (CT); RIPK1; serine/threonine-protein kinase RIP

more info or order :

Invitrogen product webpage