Occludin Polyclonal Antibody | Invitrogen PA5-20755 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Occludin Polyclonal Antibody

catalog :

PA5-20755

quantity :

100 ug

price :

US 481.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

citations: 5

Reference
Liu C, Hu S, Liu D, Xu Y, Hu K, Guo J. The effect of semen cuscutae flavonoid on Sertoli cells and blood-testis barrier in male infertility: integrating network pharmacology and experimental verification. Pharm Biol. 2023;61:986-999 pubmed publisher
Kobutree P, Tothonglor A, Roumwong A, Jindatip D, Agthong S. Curcumin reduces blood-nerve barrier abnormalities and cytotoxicity to endothelial cells and pericytes induced by cisplatin. Folia Morphol (Warsz). 2022;: pubmed publisher
Becker G, Da Silva S, Sabo A, Antal M, Kemmel V, Monassier L. Blood-Brain Barrier Permeability: Is 5-Hydroxytryptamine Receptor Type 4 a Game Changer?. Pharmaceutics. 2021;13: pubmed publisher
Hu S, Liu D, Liu S, Li C, Guo J. Lycium barbarum Polysaccharide Ameliorates Heat-Stress-Induced Impairment of Primary Sertoli Cells and the Blood-Testis Barrier in Rat via Androgen Receptor and Akt Phosphorylation. Evid Based Complement Alternat Med. 2021;2021:5574202 pubmed publisher
Riveras E, Azocar L, Moyano T, Ocares M, Molina H, Romero D, et al. Transcriptomic profiles reveal differences in zinc metabolism, inflammation, and tight junction proteins in duodenum from cholesterol gallstone subjects. Sci Rep. 2020;10:7448 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Occludin Polyclonal Antibody

Catalog # :

PA5-20755

Quantity :

100 ug

Price :

US 481.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry: 2.5 ug/mL, Western Blot: 1 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

4 C

Description :

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.

Immunogen :

A 15 amino acid peptide from near the carboxy terminus of human OCLN.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 2.5 ug/mL, Western Blot: 1 ug/mL

Aliases :

AI503564; BLCPMG; Occludin; occludin 1B; Ocl; Ocln; phosphatase 1, regulatory subunit 115; PPP1R115; tight junction protein occludin; tight junction structural protein