Akirin2 Polyclonal Antibody | Invitrogen PA5-20607 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Akirin2 Polyclonal Antibody

catalog :

PA5-20607

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

product information

Product Type :

Antibody

Product Name :

Akirin2 Polyclonal Antibody

Catalog # :

PA5-20607

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Western Blot: 1 ug/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C

Description :

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Immunogen :

A 15 amino acid peptide near the center of the human Akirin2.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1 ug/mL

Aliases :

14-3-3 beta; 2700059D21Rik; AA114675; AA522011; akirin 2; Akirin2; Akirin-2; akirin2 {ECO:0000250; AU019887; C6orf166; dJ486L4.2; EMBL:BAE81786.1}; FBI1; Fourteen-three-three beta interactant 1; fourteen-three-three beta interactant 1 {ECO:0000312; fourteen-three-three beta interacting-protein 1; RGD1307791; UniProtKB:Q53H80}