VPS53 Polyclonal Antibody | Invitrogen PA5-20548 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

VPS53 Polyclonal Antibody

catalog :

PA5-20548

quantity :

100 ug

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

citations: 1

Reference
Khakurel A, Kudlyk T, Bonifacino J, Lupashin V. The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery. Mol Biol Cell. 2021;32:1594-1610 pubmed publisher

product information

Product Type :

Antibody

Product Name :

VPS53 Polyclonal Antibody

Catalog # :

PA5-20548

Quantity :

100 ug

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 5 ug/mL, Western Blot: 0.5-1 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C

Description :

The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.

Immunogen :

An 18 amino acid peptide from near the carboxy terminus of human VPS53.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 ug/mL, Western Blot: 0.5-1 ug/mL

Aliases :

2010002A08Rik; 2310040I21Rik; 3100002B05Rik; Are1; Hccs1; hVps53L; PCH2E; pp13624; RGD1311391; SAC2 suppressor of actin mutations 2-like protein; Sacm2l; vacuolar protein sorting 52 homolog (S. cerevisiae); vacuolar protein sorting 53 (yeast); vacuolar protein sorting 53 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 52 homolog; Vacuolar protein sorting-associated protein 53 homolog; Vps52; Vps53; VPS53 GARP complex subunit; VPS53, GARP complex subunit