ZBP1 Polyclonal Antibody | Invitrogen PA5-20455 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZBP1 Polyclonal Antibody

catalog :

PA5-20455

quantity :

100 ug

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 2

Reference
Ponnusamy K, Tzioni M, Begum M, Robinson M, Caputo V, Katsarou A, et al. The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma. Haematologica. 2021;: pubmed publisher
Dhillon P, Rao C. Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production. J Virol. 2018;92: pubmed publisher

product information

Product Type :

Antibody

Product Name :

ZBP1 Polyclonal Antibody

Catalog # :

PA5-20455

Quantity :

100 ug

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 2.5 ug/mL, Immunohistochemistry: 20 ug/mL, Western Blot: 0.5-2.0 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

4 C

Description :

Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.

Immunogen :

An 18 amino acid synthetic peptide from near the carboxy terminus of human ZBP1. The immunogen is located within the last 50 amino acids of ZBP1.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 2.5 ug/mL, Immunohistochemistry: 20 ug/mL, Western Blot: 0.5-2.0 ug/mL

Aliases :

2010010H03Rik; C20orf183; Dai; Dlm1; DLM-1; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of IRFs; mZaDLM; RP4-718J7.1; Tumor stroma and activated macrophage protein DLM-1; Zbp1; Z-DNA binding protein 1; Z-DNA-binding protein 1