IFN beta Polyclonal Antibody | Invitrogen PA5-20390 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IFN beta Polyclonal Antibody

catalog :

PA5-20390

quantity :

100 ug

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; fig 7c	Ka N, Lim G, Kim S, Hwang S, Han J, Lee Y, et al. Type I IFN stimulates IFI16-mediated aromatase expression in adipocytes that promotes E2-dependent growth of ER-positive breast cancer. Cell Mol Life Sci. 2022;79:306 pubmed publisher
	C xf3 rdoba David G, Garc xed a Gim xe9 nez J, Cardoso Castelo Branco R, Carrasco S, Cannata P, Ortiz A, et al. Crosstalk between TBK1/IKKε and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury. Front Pharmacol. 2022;13:987979 pubmed publisher
	Bosnjak M, Znidar K, Sales Conniff A, Jesenko T, Markelc B, Semenova N, et al. In vitro and in vivo correlation of skin and cellular responses to nucleic acid delivery. Biomed Pharmacother. 2022;150:113088 pubmed publisher
	Ge X, Wang Y, Xie H, Li R, Zhang F, Zhao B, et al. 1,25(OH)2 D3 blocks IFNβ production through regulating STING in epithelial layer of oral lichen planus. J Cell Mol Med. 2022;26:3751-3759 pubmed publisher
	Lan X, Zhang W, Zhu J, Huang H, Mo K, Guo H, et al. dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing. Invest Ophthalmol Vis Sci. 2022;63:14 pubmed publisher
	Ka N, Lim G, Hwang S, Kim S, Lee M. IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer. Cell Rep. 2021;37:110138 pubmed publisher
	Urabe A, Doi S, Nakashima A, Ike T, Morii K, Sasaki K, et al. Klotho deficiency intensifies hypoxia-induced expression of IFN-α/β through upregulation of RIG-I in kidneys. PLoS ONE. 2021;16:e0258856 pubmed publisher
	Broad R, Jones S, Teske M, Wastall L, Hanby A, Thorne J, et al. Inhibition of interferon-signalling halts cancer-associated fibroblast-dependent protection of breast cancer cells from chemotherapy. Br J Cancer. 2021;124:1110-1120 pubmed publisher
	Liang J, Wang H, Ding W, Huang J, Zhou X, Wang H, et al. Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity. Sci Adv. 2020;6:eabc3646 pubmed publisher
	Shao S, Tsoi L, Sarkar M, Xing X, Xue K, Uppala R, et al. IFN-γ enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus. Sci Transl Med. 2019;11: pubmed publisher
	Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman H, Meriwether D, et al. Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum. J Lipid Res. 2017;58:1636-1647 pubmed publisher
	Downey J, Pernet E, Coulombe F, Allard B, Meunier I, Jaworska J, et al. RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection. PLoS Pathog. 2017;13:e1006326 pubmed publisher
	Demaria O, de Gassart A, Coso S, Gestermann N, Di Domizio J, Flatz L, et al. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc Natl Acad Sci U S A. 2015;112:15408-13 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IFN beta Polyclonal Antibody

Catalog # :

PA5-20390

Quantity :

100 ug

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 20 ug/mL, Immunohistochemistry (Paraffin): 2.5 ug/mL, Immunohistochemistry (PFA fixed): 20 ug/mL, Western Blot: 5 ug/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

4 C

Description :

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

Immunogen :

A 17 amino acid peptide from near the center of human IFN-b.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 20 ug/mL, Immunohistochemistry (Paraffin): 2.5 ug/mL, Immunohistochemistry (PFA fixed): 20 ug/mL, Western Blot: 5 ug/mL

Aliases :

Fibroblast interferon; Ifb; IFF; IFN b; IFN ß; IFNB; Ifnb1; IFNbeta; IFN-beta; IFNß; Interferon; Interferon b; Interferon beta; interferon beta 1; interferon beta 1, fibroblast; interferon beta protein; interferon, beta 1; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1

more info or order :

Invitrogen product webpage