PD-L1 Polyclonal Antibody | Invitrogen PA5-20343 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PD-L1 Polyclonal Antibody

catalog :

PA5-20343

quantity :

100 ug

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 3a	Go D, Lee S, Lee S, Woo S, Kim K, Kim K, et al. Programmed Death Ligand 1-Expressing Classical Dendritic Cells MitigateHelicobacter-Induced Gastritis. Cell Mol Gastroenterol Hepatol. 2021;12:715-739 pubmed publisher
immunoprecipitation; rat; loading ...; fig 2c immunocytochemistry; rat; loading ...; fig 5b western blot; rat; loading ...; fig 3b	Wu J, Sun L, Li H, Shen H, Zhai W, Yu Z, et al. Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype. J Neuroinflammation. 2017;14:36 pubmed publisher
	Tu L, Wang Z, Yang L, Sun X, Yao Y, Zhang P, et al. Incorporation of a TGF-β2-inhibiting oligodeoxynucleotide molecular adjuvant into a tumor cell lysate vaccine to enhance antiglioma immunity in mice. Front Immunol. 2023;14:1013342 pubmed publisher
	Jang Y, Kim T, Ryu J, Kong H, Jang S, Nam G, et al. Upregulation of programmed death ligand-1 in tumor-associated macrophages affects chemotherapeutic response in ovarian cancer cells. PLoS ONE. 2023;18:e0277285 pubmed publisher
	Yong J, Gr xf6 ger S, von Bremen J, Meyle J, Ruf S. Immunorthodontics: PD-L1, a Novel Immunomodulator in Cementoblasts, Is Regulated by HIF-1α under Hypoxia. Cells. 2022;11: pubmed publisher
	Chung Y, Tsai W, Khan P, Ma J, Berek J, Larrick J, et al. FOXO3-dependent suppression of PD-L1 promotes anticancer immune responses via activation of natural killer cells. Am J Cancer Res. 2022;12:1241-1263 pubmed
	Krache A, Fontan C, Pestourie C, Bardi xe8 s M, Bouvet Y, Payoux P, et al. Preclinical Pharmacokinetics and Dosimetry of an 89Zr Labelled Anti-PDL1 in an Orthotopic Lung Cancer Murine Model. Front Med (Lausanne). 2021;8:741855 pubmed publisher
	Wang X, Tokheim C, Gu S, Wang B, Tang Q, Li Y, et al. In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target. Cell. 2021;184:5357-5374.e22 pubmed publisher
	Panza S, Malivindi R, Caruso A, Russo U, Giordano F, Gy x151 rffy B, et al. Novel Insights into the Antagonistic Effects of Losartan against Angiotensin II/AGTR1 Signaling in Glioblastoma Cells. Cancers (Basel). 2021;13: pubmed publisher
	Saar M, Narits J, M xe4 gi L, Aasp xf5 llu H, Vapper A, Kase M, et al. Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase. Mol Clin Oncol. 2021;15:211 pubmed publisher
	Nasarre P, Garcia D, Siegel J, Bonilla I, Mukherjee R, Hilliard E, et al. Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma. Cancers (Basel). 2021;13: pubmed publisher
	Rowswell Turner R, Singh R, Urh A, Yano N, Kim K, Khazan N, et al. HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression. J Immunol. 2021;206:2478-2488 pubmed publisher
	Zaidi A, Kelly R, Gorbunova A, Omstead A, Salvitti M, Zheng P, et al. Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model. Oncotarget. 2021;12:292-303 pubmed publisher
	Mohapatra P, Shriwas O, Mohanty S, Ghosh A, Smita S, Kaushik S, et al. CMTM6 drives cisplatin resistance by regulating Wnt signaling through ENO-1/AKT/GSK3β axis. JCI Insight. 2021;: pubmed publisher
	Coronel M, MARTIN K, Hunckler M, Barber G, O Neill E, Medina J, et al. Immunotherapy via PD-L1-presenting biomaterials leads to long-term islet graft survival. Sci Adv. 2020;6:eaba5573 pubmed publisher
	Gelsomino L, Naimo G, Malivindi R, Augimeri G, Panza S, Giordano C, et al. Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression. Cancers (Basel). 2020;12: pubmed publisher
	Song M, Wang C, Wang H, Zhang T, Li J, Benezra R, et al. Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response. Oncoimmunology. 2020;9:1746148 pubmed publisher
	Tanaka E, Miyakawa Y, Kishikawa T, Seimiya T, Iwata T, Funato K, et al. Expression of circular RNA CDR1‑AS in colon cancer cells increases cell surface PD‑L1 protein levels. Oncol Rep. 2019;42:1459-1466 pubmed publisher
	Huang X, Xie X, Wang H, Xiao X, Yang L, Tian Z, et al. PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a. J Exp Clin Cancer Res. 2017;36:129 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PD-L1 Polyclonal Antibody

Catalog # :

PA5-20343

Quantity :

100 ug

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 0.5 ug/mL, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.

Immunogen :

A 17 amino acid peptide from near the center of human PDL-1.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/mL, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1

more info or order :

Invitrogen product webpage