DRAM Polyclonal Antibody | Invitrogen PA5-20336 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DRAM Polyclonal Antibody

catalog :

PA5-20336

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

DRAM Polyclonal Antibody

Catalog # :

PA5-20336

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 2-2.5 ug/mL, Immunohistochemistry (PFA fixed): 20 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C

Description :

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Immunogen :

A 16 amino acid peptide from near the amino terminus of human DRAM.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 2-2.5 ug/mL, Immunohistochemistry (PFA fixed): 20 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

1200002N14Rik; Damage-regulated autophagy modulator; DNA damage regulated autophagy modulator 1; DNA damage-regulated autophagy modulator protein 1; DNA-damage regulated autophagy modulator 1; DRAM; Dram1; FLJ11259; hypothetical protein FLJ11259; zgc:101811