TIM-1 Polyclonal Antibody | Invitrogen PA5-20244 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TIM-1 Polyclonal Antibody

catalog :

PA5-20244

quantity :

100 ug

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 7

Reference
Packialakshmi B, Burmeister D, Anderson J, Morgan J, Cannon G, Kiang J, et al. A clinically-relevant mouse model that displays hemorrhage exacerbates tourniquet-induced acute kidney injury. Front Physiol. 2023;14:1240352 pubmed publisher
Zavala Guevara I, Ortega Romero M, Narváez Morales J, Jacobo Estrada T, Lee W, Arreola Mendoza L, et al. Increased Endocytosis of Cadmium-Metallothionein through the 24p3 Receptor in an In Vivo Model with Reduced Proximal Tubular Activity. Int J Mol Sci. 2021;22: pubmed publisher
Balas M, Popescu Din I, Hermenean A, Cinteza L, Dinischiotu A. Exposure to Iron Oxide Nanoparticles Coated with Phospholipid-Based Polymeric Micelles Induces Renal Transitory Biochemical and Histopathological Changes in Mice. Materials (Basel). 2021;14: pubmed publisher
Nanto Hara F, Kanemitsu Y, Fukuda S, Kikuchi K, Asaji K, Saigusa D, et al. The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease. Nephrol Dial Transplant. 2020;35:250-264 pubmed publisher
Zheng X, Xu K, Chen L, Zhou Y, Jiang J. Prognostic value of TIM-1 expression in human non-small-cell lung cancer. J Transl Med. 2019;17:178 pubmed publisher
Papu John A, Kundu S, Pushpakumar S, Amin M, Tyagi S, Sen U. Hydrogen sulfide inhibits Ca2+-induced mitochondrial permeability transition pore opening in type-1 diabetes. Am J Physiol Endocrinol Metab. 2019;317:E269-E283 pubmed publisher
Jeong B, Lee H, Park C, Kang J, Yu S, Choi D, et al. Oxidative stress caused by activation of NADPH oxidase 4 promotes contrast-induced acute kidney injury. PLoS ONE. 2018;13:e0191034 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TIM-1 Polyclonal Antibody

Catalog # :

PA5-20244

Quantity :

100 ug

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1:50, Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 1-8 ug/mL

Species :

Human

Isotype :

IgG

Storage :

4 C

Description :

CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.

Immunogen :

A 16 amino acid peptide from near the amino terminus of human TIM-1.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50, Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 1-8 ug/mL

Aliases :

AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1