IL-23 p19 Polyclonal Antibody | Invitrogen PA5-20239 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-23 p19 Polyclonal Antibody

catalog :

PA5-20239

quantity :

100 ug

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 3

Reference
Dajnoki Z, Somogyi O, Medgyesi B, Jenei A, Szab xf3 L, G xe1 sp xe1 r K, et al. Primary alterations during the development of hidradenitis suppurativa. J Eur Acad Dermatol Venereol. 2022;36:462-471 pubmed publisher
Rätsep M, Moore S, Jafri S, Mitchell M, Brady H, Mandelboim O, et al. Spontaneous pulmonary hypertension in genetic mouse models of natural killer cell deficiency. Am J Physiol Lung Cell Mol Physiol. 2018;315:L977-L990 pubmed publisher
Hussain S, Reed L, Krasnick B, MIRANDA CARBONI G, Fields R, Bi Y, et al. IL23 and TGF-ÃŸ diminish macrophage associated metastasis in pancreatic carcinoma. Sci Rep. 2018;8:5808 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IL-23 p19 Polyclonal Antibody

Catalog # :

PA5-20239

Quantity :

100 ug

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Paraffin): 2 ug/mL, Immunohistochemistry (PFA fixed): 20 ug/mL, Western Blot: 0.25-2 ug/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

4 C

Description :

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN- . Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN- production by naive and memory T cells, as compared to IL-12.

Immunogen :

A 17 amino acid peptide from near the amino terminus of human IL-23.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 2 ug/mL, Immunohistochemistry (PFA fixed): 20 ug/mL, Western Blot: 0.25-2 ug/mL

Aliases :

il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798