TNF alpha Polyclonal Antibody | Invitrogen PA5-19810 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TNF alpha Polyclonal Antibody

catalog :

PA5-19810

quantity :

100 µg

price :

US 450.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 2	Omarniyaz Z, Yu Y, Yang T, Shan L, Miao W, Reyimu R, et al. Anti-tumor effects of Abnormal Savda Munziq on the transplanted cervical cancer (U27) mouse model. BMC Complement Altern Med. 2016;16:477 pubmed
	Ye J, Wen Z, Wu T, Chen L, Sheng L, Wang C, et al. Single-Cell Sequencing Reveals the Optimal Time Window for Anti-Inflammatory Treatment in Spinal Cord Injury. Adv Biol (Weinh). 2023;7:e2300098 pubmed publisher
	Mohamed H, El Kamel A, Hammad G, Heikal L. Design of Targeted Flurbiprofen Biomimetic Nanoparticles for Management of Arthritis: In Vitro and In Vivo Appraisal. Pharmaceutics. 2022;14: pubmed publisher
	Warnecke A, Harre J, Shew M, Mellott A, Majewski I, Durisin M, et al. Successful Treatment of Noise-Induced Hearing Loss by Mesenchymal Stromal Cells: An RNAseq Analysis of Protective/Repair Pathways. Front Cell Neurosci. 2021;15:656930 pubmed publisher
	Potor L, Hendrik Z, Patsalos A, Katona x, M xe9 hes G, P xf3 liska S, et al. Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis. Antioxid Redox Signal. 2021;35:917-950 pubmed publisher
	Mouritzen M, Petkovic M, Qvist K, Poulsen S, Alarico S, Leal E, et al. Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiota. Mol Ther Methods Clin Dev. 2021;20:726-739 pubmed publisher
	Éva Sikura K, Combi Z, Potor L, Szerafin T, Hendrik Z, Mehes G, et al. Hydrogen sulfide inhibits aortic valve calcification in heart via regulating RUNX2 by NF-κB, a link between inflammation and mineralization. J Adv Res. 2021;27:165-176 pubmed publisher

image

image 1 :

Western blot analysis of HeLa Whole Cell Lysate using PA5-19810, TNF alpha primary antibody at a dilution of 1 ug/ml (lane 1). PA5-19810 staining of Mouse Liver Tissue Lysate at a dilution of 1 ug/ml (lane 2). Blot treated with a secondary HRP-conjugated Goat polyclonal anti-Rabbit antibody was used at a dilution of 1:3000.

product information

Product Type :

Antibody

Product Name :

TNF alpha Polyclonal Antibody

Catalog # :

PA5-19810

Quantity :

100 µg

Price :

US 450.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1 µg/mL, Western Blot: 1 µg/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20°C or -80°C if preferred

Description :

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

Immunogen :

Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human TNF alpha.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1 µg/mL, Western Blot: 1 µg/mL

Aliases :

APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor

more info or order :

Invitrogen product webpage