GCLC Polyclonal Antibody | Invitrogen PA5-19702 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GCLC Polyclonal Antibody

catalog :

PA5-19702

quantity :

100 µg

price :

US 429

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000	Cheng L, Liu J, Li B, Liu S, Li X, Tu H. Cigarette Smoke-Induced Hypermethylation of the GCLC Gene Is Associated With COPD. Chest. 2016;149:474-482 pubmed publisher
	Liu C, Hua K, Li K, Kao H, Hong R, Ko J, et al. Histone Methyltransferase G9a Drives Chemotherapy Resistance by Regulating the Glutamate-Cysteine Ligase Catalytic Subunit in Head and Neck Squamous Cell Carcinoma. Mol Cancer Ther. 2017;16:1421-1434 pubmed publisher
	Weerachayaphorn J, Amaya M, Spirli C, Chansela P, Mitchell Richards K, Ananthanarayanan M, et al. Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes. Gastroenterology. 2015;149:211-222.e10 pubmed publisher

product information

Product Type :

Antibody

Product Name :

GCLC Polyclonal Antibody

Catalog # :

PA5-19702

Quantity :

100 µg

Price :

US 429

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 5 µg/mL, Western Blot: 1 µg/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.

Immunogen :

Synthetic peptide conjugated to KLH derived from within residues 50 - 150 of Human GCLC.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL, Western Blot: 1 µg/mL

Aliases :

cb1049; D9Wsu168e; EGK_15023; fe36e11; gamma GCS-HS; gamma-ECS; Gamma-glutamylcysteine synthetase; gamma-glutamylcysteine synthetase heavy subunit; GCL; Gclc; GCS; GCS heavy chain; Ggcs-hs; GLCL; GLCLC; GLCL-H; glutamate-cysteine ligase catalytic subunit; Glutamate--cysteine ligase catalytic subunit; glutamate-cysteine ligase, catalytic subunit; Glutamylcysteine gamma synthetase light chain; wu:fe36e11