Phospho-SP1 (Thr453) Polyclonal Antibody | Invitrogen PA5-19658 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-SP1 (Thr453) Polyclonal Antibody

catalog :

PA5-19658

quantity :

100 µg

price :

US 413.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Long J, Liao G, Wang Y, Tang D. Specific protein 1, c-Abl and ERK1/2 form a regulatory loop. J Cell Sci. 2019;132: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-SP1 (Thr453) Polyclonal Antibody

Catalog # :

PA5-19658

Quantity :

100 µg

Price :

US 413.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1 µg/mL

Species :

Human, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

Immunogen :

Synthetic peptide conjugated to KLH derived from within residues 450 - 550 of Human SP1, phosphorylated at pThr453

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1 µg/mL

Aliases :

1110003E12Rik; AA450830; AI845540; HGNC:11205; SP1; Sp1 transcription factor; Sp1-1; specificity protein 1; trans-acting transcription factor 1; transcription factor Sp1; TSFP1