CaV2.1 Polyclonal Antibody | Invitrogen PA5-19598 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CaV2.1 Polyclonal Antibody

catalog :

PA5-19598

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat; fig 2	McKasson M, Clardy S, Clawson S, Hill K, Wood B, Carlson N, et al. Voltage-gated calcium channel autoimmune cerebellar degeneration: Case and study of cytotoxicity. Neurol Neuroimmunol Neuroinflamm. 2016;3:e222 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CaV2.1 Polyclonal Antibody

Catalog # :

PA5-19598

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Mouse, Rat

Applications :

Immunohistochemistry (Frozen): 1:100, Western Blot: Assay-Dependent

Species :

Mouse, Rat

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the n-repeats occur in the 3 UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the n-repeats which encode a polyglutamine tract. Expansion of the n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.

Immunogen :

Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Rat CACNA1A.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): 1:100, Western Blot: Assay-Dependent

Aliases :

alpha1A; APCA; BccA1; BI; brain calcium channel 1; brain calcium channel I; brain class A; Caca1a; Cach4; CACN3; CACNA1A; Cacnl1a4; calcium channel alpha 1A; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide isoform 4; Calcium channel, L type, alpha-1 polypeptide, isoform 4; calcium channel, voltage-dependent, alpha 1A subunit; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; calcium voltage-gated channel subunit alpha1 A; Cav2.1; Ccha1a; EA2; fetal brain Ca2+ voltage-gated channel alpha1A pore-forming subunit; FHM; HPCA; la; leaner; MHP; MHP1; nmf352; Rat brain class A; rbA-1; RBA-I; rkr; rocker; SCA6; tg; tottering; voltage-dependent P/Q-type calcium channel subunit alpha-1A; Voltage-gated calcium channel subunit alpha Cav2.1

more info or order :

Invitrogen product webpage