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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Lamin B1 Polyclonal Antibody
catalog :
PA5-19468
quantity :
100 µg
price :
US 450.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 7
Jahn D, Sutor D, Dorbath D, Weiß J, Götze O, Schmitt J, et al. Farnesoid X receptor-dependent and -independent pathways mediate the transcriptional control of human fibroblast growth factor 19 by vitamin A. Biochim Biophys Acta. 2016;1859:381-92 pubmed publisher
Li D, B xfc hler M, Runft S, Gerold G, Marek K, Baumg xe4 rtner W, et al. ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler's murine encephalomyelitis virus. Sci Rep. 2023;13:10960 pubmed publisher
Betlej G, Z x105 bek T, Lewi x144 ska A, B x142 oniarz D, Rzeszutek I, Wnuk M. RNA 5-methylcytosine status is associated with DNMT2/TRDMT1 nuclear localization in osteosarcoma cell lines. J Bone Oncol. 2022;36:100448 pubmed publisher
Gargaro M, Scalisi G, Manni G, Briseño C, Bagadia P, Durai V, et al. Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication. Immunity. 2022;55:1032-1050.e14 pubmed publisher
Krastev D, Li S, Sun Y, Wicks A, Hoslett G, Weekes D, et al. The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin. Nat Cell Biol. 2022;24:62-73 pubmed publisher
D x105 browska K, Skowro x144 ska K, Popek M, Albrecht J, Zieli x144 ska M. The Role of Nrf2 Transcription Factor and Sp1-Nrf2 Protein Complex in Glutamine Transporter SN1 Regulation in Mouse Cortical Astrocytes Exposed to Ammonia. Int J Mol Sci. 2021;22: pubmed publisher
Mikac S, Rychłowski M, Dziadosz A, Szabelska Berȩsewicz A, Fahraeus R, Hupp T, et al. Identification of a Stable, Non-Canonically Regulated Nrf2 Form in Lung Cancer Cells. Antioxidants (Basel). 2021;10: pubmed publisher
Kilgas S, Singh A, Paillas S, Then C, Torrecilla I, Nicholson J, et al. p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation. Cell Rep. 2021;35:109153 pubmed publisher
Rajendran P, Ammar R, Al Saeedi F, Mohamed M, ElNaggar M, Al ramadan S, et al. Kaempferol Inhibits Zearalenone-Induced Oxidative Stress and Apoptosis via the PI3K/Akt-Mediated Nrf2 Signaling Pathway: In Vitro and In Vivo Studies. Int J Mol Sci. 2020;22: pubmed publisher
Yewdell W, Kim Y, Chowdhury P, Lau C, Smolkin R, Belcheva K, et al. A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization. Immunity. 2020;53:952-970.e11 pubmed publisher
Czarnecka A, Milewski K, Albrecht J, Zielinska M. The Status of Bile Acids and Farnesoid X Receptor in Brain and Liver of Rats with Thioacetamide-Induced Acute Liver Failure. Int J Mol Sci. 2020;21: pubmed publisher
Weber J, Rajan S, Schremmer C, Chao Y, Krasteva Christ G, Kannler M, et al. TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema. JCI Insight. 2020;5: pubmed publisher
van der Wel T, Hilhorst R, den Dulk H, van den Hooven T, Prins N, Wijnakker J, et al. Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis. Nat Commun. 2020;11:3216 pubmed publisher
Huang J, Acharya A, Taglialatela A, Nambiar T, Cuella Martin R, Leuzzi G, et al. MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage. Nat Commun. 2020;11:2948 pubmed publisher
Bendiks L, Geiger F, Gudermann T, Feske S, Dietrich A. Store-operated Ca2+ entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration. Sci Rep. 2020;10:6812 pubmed publisher
Ruggieri S, De Giorgis M, Annese T, Tamma R, Notarangelo A, Marzullo A, et al. Dp71 Expression in Human Glioblastoma. Int J Mol Sci. 2019;20: pubmed publisher
Dorland Y, Cornelissen A, Kuijk C, Tol S, Hoogenboezem M, van Buul J, et al. Nuclear shape, protrusive behaviour and in vivo retention of human bone marrow mesenchymal stromal cells is controlled by Lamin-A/C expression. Sci Rep. 2019;9:14401 pubmed publisher
Bertero A, Fields P, Smith A, Leonard A, Beussman K, Sniadecki N, et al. Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy. J Cell Biol. 2019;218:2919-2944 pubmed publisher
Zeng S, Seifert A, Zhang J, Kim T, Bowler T, Cavnar M, et al. ETV4 collaborates with Wnt/β-catenin signaling to alter cell cycle activity and promote tumor aggressiveness in gastrointestinal stromal tumor. Oncotarget. 2017;8:114195-114209 pubmed publisher
Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang J, et al. Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers. Mol Cell. 2017;68:414-430.e8 pubmed publisher
Vaz B, Popovic M, Newman J, Fielden J, Aitkenhead H, Halder S, et al. Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair. Mol Cell. 2016;64:704-719 pubmed publisher
Lewinska A, Wnuk M, Grabowska W, Zabek T, Semik E, Sikora E, et al. Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells. Toxicol Lett. 2015;233:227-38 pubmed publisher
image
image 1 :
Invitrogen PA5-19468 image 1
Western blot analysis of HeLa Whole Cell Lysate using PA5-19468, Lamin B1 primary antibody at a dilution of 1 ug/ml (lane 1). PA5-19468 staining of Jurkat Whole Cell Lysate at a dilution of 1 ug/ml (Lane 2). PA5-19468 staining of A431 Whole Cell Lysate at a dilution of 1 ug/ml (lane 3). Blot treated with a secondary HRP-conjugated Goat polyclonal anti-Rabbit antibody was used at a dilution of 1:3000.
image 2 :
Invitrogen PA5-19468 image 2
Immunohistochemical (formalin-fixed, paraffin-embedded) staining of Human Liver tissue using PA5-19468, anti-Lamin B1 antibody. Primary antibody was used at a concentration of 1 ug/ml and exposed for 8 mins at room temp. The sample was pretreated using heat mediated antigen retrieval with Sodium Citrate Buffer (pH6 / 20mins). The detection method was a HRP conjugated polymer, DAB chromogen and the sample was counterstained with haematoxylin and mounted with DPX.
product information
Product Type :
Antibody
Product Name :
Lamin B1 Polyclonal Antibody
Catalog # :
PA5-19468
Quantity :
100 µg
Price :
US 450.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 0.1 µg/mL, Immunohistochemistry (Paraffin): 0.1-1.0 µg/mL, Western Blot: 0.1 µg/mL
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Defects in the LMNB1 gene can cause Leukodystrophy, demyelinating, autosomal dominant, adult-onset (ADLD).
Immunogen :
Synthetic peptide conjugated to KLH derived from within residues 400 - 500 of Mouse Lamin B1.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 0.1 µg/mL, Immunohistochemistry (Paraffin): 0.1-1.0 µg/mL, Western Blot: 0.1 µg/mL
Aliases :
0710005A05Rik; ADLD; C-flanking peptide of NPY; CPON; fc06g01; I79_003938; lamin B1; lamin B1 L homeolog; lamin B1 protein; lamin-b; lamin-B1; Lamin-L(I); LMN; LMN2; LMNB; LMNB1; lmnb1 protein; lmnb1.L; MGC111419; Neuropeptide tyrosine; Neuropeptide Y; NPY; NPY02; prepro-neuropeptide Y; pro-neuropeptide Y; PYY4; RATNPY; RATNPY02; unnamed protein product; wu:fc06g01; XELAEV_18007951mg
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA