Alpha-Smooth Muscle Actin Polyclonal Antibody | Invitrogen PA5-19465 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Alpha-Smooth Muscle Actin Polyclonal Antibody

catalog :

PA5-19465

quantity :

100µg

price :

399.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, zebrafish , domestic horse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 4c immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a	Biasin V, Wygrecka M, Marsh L, Becker Pauly C, Brcic L, Ghanim B, et al. Meprin β contributes to collagen deposition in lung fibrosis. Sci Rep. 2017;7:39969 pubmed publisher
	Pattanaik S, Arbra C, Bainbridge H, Dennis S, Fann S, Yost M. Vascular Tissue Engineering Using Scaffold-Free Prevascular Endothelial-Fibroblast Constructs. Biores Open Access. 2019;8:1-15 pubmed publisher
	Xie X, Percipalle P. Elevated transforming growth factor ? signaling activation in ?-actin-knockout mouse embryonic fibroblasts enhances myofibroblast features. J Cell Physiol. 2018;: pubmed publisher
	Reebye V, Huang K, Lin V, Jarvis S, Cutilas P, Dorman S, et al. Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer. Oncogene. 2018;37:3216-3228 pubmed publisher
	Toghill B, Saratzis A, Freeman P, Sylvius N, Bown M. SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells. Clin Epigenetics. 2018;10:29 pubmed publisher
	Ntokou A, Szibor M, Rodríguez Castillo J, Quantius J, Herold S, El Agha E, et al. A novel mouse Cre-driver line targeting Perilipin 2-expressing cells in the neonatal lung. Genesis. 2017;55: pubmed publisher
	Higuchi A, Kao S, Ling Q, Chen Y, Li H, Alarfaj A, et al. Long-term xeno-free culture of human pluripotent stem cells on hydrogels with optimal elasticity. Sci Rep. 2015;5:18136 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Alpha-Smooth Muscle Actin Polyclonal Antibody

Catalog # :

PA5-19465

Quantity :

100µg

Price (USD) :

399.00 USD

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Equine, Human, Mouse, Rat, Zebrafish

Applications :

Immunohistochemistry (Frozen): 1:1000, Immunohistochemistry (Paraffin): Assay-Dependent, Immunohistochemistry (PFA fixed): 1:200, Western Blot: 1 µg/mL

Species :

Equine, Human, Mouse, Rat, Zebrafish

Isotype :

IgG

Storage :

-20°C or -80°C if preferred

Description :

Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actin being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. In particular, smooth muscle actin is an alpha actin that is found in skeletal muscle. Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. Smooth muscle actin is found on smooth muscle vessel walls, gut wall, myometrium, myoepithelial cells in breast and salivary glands. Defects in the smooth muscle actin gene cause aortic aneurysm familial thoracic type 6. Actin isoforms differ slightly in their N-terminus and the sequences of each are perfectly conserved in higher vertebrates. Alpha-smooth muscle actin is abundant in vascular and visceral smooth muscle cells. In addition, it has also been shown that smooth muscle actin appear in stress fibers of fibroblastic cells during pathological situations involving contractile phenomena such as wound healing and fibrocontractive diseases. Multiple alternatively spliced variants of smooth muscle actin have been identified.

Immunogen :

Synthetic peptide derived from within residues 1 - 100 of Human alpha smooth muscle Actin.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): 1:1000, Immunohistochemistry (Paraffin): Assay-Dependent, Immunohistochemistry (PFA fixed): 1:200, Western Blot: 1 µg/mL

Aliases :

0610041G09Rik; aat6; ACT-4; Acta2; acta2.L; acta2.S; actin; actin alpha 2, smooth muscle; actin, alpha 2, smooth muscle, aorta; actin, alpha 2, smooth muscle, aorta L homeolog; actin, alpha 2, smooth muscle, aorta S homeolog; actin, alpha, vascular smooth muscle; actin, aortic smooth muscle; Actin, aortic smooth muscle, intermediate form; ACTSA; Actvs; alpha actin 2; alpha smooth muscle actin; alpha-actin; Alpha-actin-2; alpha-cardiac actin; alphaSMA; alpha-SM-actin; alpha-smooth muscle actin; ASMA; a-sma; Cell growth-inhibiting gene 46 protein; GIG46; hypothetical protein LOC515610; LOW QUALITY PROTEIN: actin, aortic smooth muscle; mymy5; SM actin; sma; SMactin; sm-actin; SMalphaA; smooth muscle; smooth muscle alpha-actin; vascular smooth muscle alpha-actin; wu:fb63d03; XELAEV_18034370mg