MEPCE Polyclonal Antibody | Invitrogen PA5-18813 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MEPCE Polyclonal Antibody

catalog :

PA5-18813

quantity :

100 ug

price :

US 474.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

MEPCE Polyclonal Antibody

Catalog # :

PA5-18813

Quantity :

100 ug

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Goat

Reactivity :

Human, Rat

Applications :

Immunohistochemistry (Paraffin): 5-10 ug/mL, Western Blot: 1-3 ug/mL

Species :

Human, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). [UniProt]

Immunogen :

Synthetic peptide sequence (KQQRKFQYGNYCK) corresponding to the internal amino acids of MEPCE (aa 408-420).

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 5-10 ug/mL, Western Blot: 1-3 ug/mL

Aliases :

7SK snRNA methylphosphate capping enzyme; BCDIN3; Bicoid-interacting protein 3 homolog; bin3 homolog; bin3, bicoid-interacting 3; bin3, bicoid-interacting 3, homolog; Bipl1; D5Wsu46e; fc59f06; FLJ20257; Mepce; methylphosphate capping enzyme; si:ch211-283h6.1; wu:fc59f06; zBCDIN3