MPZ Polyclonal Antibody | Invitrogen PA5-18773 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MPZ Polyclonal Antibody

catalog :

PA5-18773

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:3000; fig 3	Fernando R, Cotter L, Perrin Tricaud C, Berthelot J, Bartolami S, Pereira J, et al. Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway. Nat Commun. 2016;7:12186 pubmed publisher
	Gautier B, Hajjar H, Soares S, Berthelot J, Deck M, Abbou S, et al. AAV2/9-mediated silencing of PMP22 prevents the development of pathological features in a rat model of Charcot-Marie-Tooth disease 1 A. Nat Commun. 2021;12:2356 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MPZ Polyclonal Antibody

Catalog # :

PA5-18773

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Goat

Reactivity :

Rat

Applications :

Western Blot: 0.1-0.3 ug/mL

Species :

Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

Immunogen :

Synthetic peptide sequence (DHSRSTKAVSEK) corresponding to the internal amino acids of MPZ (aa 224-232).

Format :

Liquid

Applications w/Dilutions :

Western Blot: 0.1-0.3 ug/mL

Aliases :

Charcot-Marie-Tooth neuropathy 1B; CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; MPZ; Myelin peripheral protein; myelin protein P0; Myelin protein zero; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B); P0; P-zero

more info or order :

Invitrogen product webpage