Arginase 1 Polyclonal Antibody | Invitrogen PA5-18684 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Arginase 1 Polyclonal Antibody

catalog :

PA5-18684

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; rat; loading ...; fig 3c	Guzmán Ruíz M, Herrera González A, Jiménez A, Candelas Juárez A, Quiroga Lozano C, Castillo Díaz C, et al. Protective effects of intracerebroventricular adiponectin against olfactory impairments in an amyloid β1-42 rat model. BMC Neurosci. 2021;22:14 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Arginase 1 Polyclonal Antibody

Catalog # :

PA5-18684

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Goat

Reactivity :

Mouse, Rat

Applications :

Immunocytochemistry: 10 ug/mL, Western Blot: 1-3 ug/mL

Species :

Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.

Immunogen :

Synthetic peptide sequence (NHKPETDYLKPPK) corresponding to the C-terminus amino acids of Arg1 (aa 311-323).

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 10 ug/mL, Western Blot: 1-3 ug/mL

Aliases :

AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase

more info or order :

Invitrogen product webpage