TRPC6 Polyclonal Antibody | Invitrogen PA5-18414 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TRPC6 Polyclonal Antibody

catalog :

PA5-18414

quantity :

100 ug

price :

US 438.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, flow cytometry

product information

Product Type :

Antibody

Product Name :

TRPC6 Polyclonal Antibody

Catalog # :

PA5-18414

Quantity :

100 ug

Price :

US 438.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Goat

Reactivity :

Human

Applications :

Flow Cytometry: 10 ug/mL, Western Blot: 0.3-1 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Trpc6 forms a receptor-activated calcium channel in the cell membrane. The Trpc6 channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of the Trpc6 channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in the Trpc6 gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). Further, Trpc6 is a member of the mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the “canonical TRP” (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, Trpc6 acts as a non-selective store-independent receptor-activated cation channel. Trpc6 is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo. Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.

Immunogen :

Synthetic peptide sequence (EKLSMEPNQEETN) corresponding to the C-terminus amino acids of TRPC6 (aa 918-931).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 10 ug/mL, Western Blot: 0.3-1 ug/mL

Aliases :

AV025995; bZ1P14.9; calcium entry channel; FLJ11098; FLJ14863; focal segmental glomerulosclerosis 2; FSGS2; HGNC:12338; LLHWJM002; LLHWJM003; LLHWJM004; mtrp6; Short transient receptor potential channel 6; short transient receptor potential channel 6; short transient receptor potential channel 6a; si:rp71-1p14.9; transient receptor potential cation channel subfamily C member 6; transient receptor potential cation channel subfamily c member 6a; transient receptor potential cation channel TRPC6; transient receptor potential cation channel, subfamily C, member 6; transient receptor potential cation channel, subfamily C, member 6a; transient receptor potential channel 6; transient receptor potential channel subfamily C member 6; transient receptor protein 6; TRP6; TRP-6; trp6A; TRPC6; trpc6a; Trrp6