Arginase 1 Polyclonal Antibody | Invitrogen PA5-18392 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Arginase 1 Polyclonal Antibody

catalog :

PA5-18392

quantity :

100 ug

price :

US 514.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, pigs

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 1

Reference
Latif A, Fisher L, Dundas A, Cuzzucoli Crucitti V, Imir Z, Lawler K, et al. Microparticles Decorated with Cell-Instructive Surface Chemistries Actively Promote Wound Healing. Adv Mater. 2022;:e2208364 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Arginase 1 Polyclonal Antibody

Catalog # :

PA5-18392

Quantity :

100 ug

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Goat

Reactivity :

Human, Mouse, Porcine, Rat

Applications :

Flow Cytometry: 10 ug/mL, Immunocytochemistry: 10 ug/mL, Immunohistochemistry (Paraffin): 3.75 ug/mL, Western Blot: 0.01-0.03 ug/mL

Species :

Human, Mouse, Porcine, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.

Immunogen :

Synthetic peptide sequence (CFGLAREGNHKPID) corresponding to the C-terminus amino acids of ARG1 (aa 303-316).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 10 ug/mL, Immunocytochemistry: 10 ug/mL, Immunohistochemistry (Paraffin): 3.75 ug/mL, Western Blot: 0.01-0.03 ug/mL

Aliases :

AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase