Parvalbumin Polyclonal Antibody | Invitrogen PA5-18389 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Parvalbumin Polyclonal Antibody

catalog :

PA5-18389

quantity :

100 ug

price :

US 470.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, flow cytometry, immunohistochemistry - free floating section

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - free floating section; mouse; 1:2000; loading ...; fig 4e	Fu H, Rodriguez G, Herman M, Emrani S, Nahmani E, Barrett G, et al. Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease. Neuron. 2017;93:533-541.e5 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Parvalbumin Polyclonal Antibody

Catalog # :

PA5-18389

Quantity :

100 ug

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Goat

Reactivity :

Human, Rat

Applications :

Flow Cytometry: 10 ug/mL, Western Blot: 0.01-0.3 ug/mL

Species :

Human, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.

Immunogen :

Synthetic peptide sequence (GVDEFSTLVAES) corresponding to the C-terminus amino acids of PVALB (aa 99-110).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 10 ug/mL, Western Blot: 0.01-0.3 ug/mL

Aliases :

D22S749; HGNC:9704; MGC116759; PALB1; Parv; parvalbumin; Parvalbumin (calcium binding protein); parvalbumin alpha; PV; Pva; PVALB

more info or order :

Invitrogen product webpage