POMC Polyclonal Antibody | Invitrogen PA5-18368 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

POMC Polyclonal Antibody

catalog :

PA5-18368

quantity :

100 ug

price :

US 454.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation, immunohistochemistry knockout validation

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry knockout validation; mouse; 1:100; loading ...; fig s3c western blot knockout validation; mouse; 1:4000; loading ...; fig s3d immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1c immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1c	Deshpande D, Agarwal N, Fleming T, Gaveriaux Ruff C, Klose C, Tappe Theodor A, et al. Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy. Nat Commun. 2021;12:426 pubmed publisher
	Garc xed a Mart xed nez A, Cano D, Flores Mart xed nez A, Gil J, Puig Domingo M, Webb S, et al. Why don't corticotroph tumors always produce Cushing's disease?. Eur J Endocrinol. 2019;181:351-361 pubmed publisher

product information

Product Type :

Antibody

Product Name :

POMC Polyclonal Antibody

Catalog # :

PA5-18368

Quantity :

100 ug

Price :

US 454.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Goat

Reactivity :

Human

Applications :

Flow Cytometry: 10 ug/mL, Immunohistochemistry (Paraffin): 2-4 ug/mL, Western Blot: 0.3-2 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Immunogen :

Synthetic peptide sequence (NAIIKNAYKKGE) corresponding to the C-terminus amino acids of POMC (aa 256-267).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 10 ug/mL, Immunohistochemistry (Paraffin): 2-4 ug/mL, Western Blot: 0.3-2 ug/mL

Aliases :

ACTH; adrenal corticotropic hormone; adrenocorticotropic hormone; adrenocorticotropin; alpha-melanocyte stimulating hormone; alpha-melanocyte-stimulating hormone; alphaMSH; alpha-MSH; BE; beta-endorphin; Beta-LPH; beta-melanocyte-stimulating hormone; beta-MSH; CLIP; Corticotropin; Corticotropin-like intermediary peptide; corticotropin-lipotropin; Gamma-LPH; gamma-MSH; lipotr; Lipotropin beta; lipotropin gamma; LPH; Melanocyte-stimulating hormone alpha; Melanocyte-stimulating hormone beta; Melanotropin alpha; melanotropin beta; Melanotropin gamma; met-enkephalin; MSH; Npp; opiomelanocortin prepropeptide; OTTHUMP00000119991; OTTHUMP00000200964; POC; Pomc; Pomc1; Pomc-1; Pomc2; Potential peptide; Precursor of MSH; pro-ACTH-endorphin; proopiomelanocortin; pro-opiomelanocortin; proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin); proopiomelanocortin preproprotein; proopiomelanocortin, beta (endorphin, beta); pro-opiomelanocortin-alpha; proopoimelanocortin, beta (endorphin, beta)

more info or order :

Invitrogen product webpage