Tankyrase Polyclonal Antibody | Invitrogen PA5-17931 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tankyrase Polyclonal Antibody

catalog :

PA5-17931

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Product Type :

Antibody

Product Name :

Tankyrase Polyclonal Antibody

Catalog # :

PA5-17931

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Goat

Reactivity :

Human

Applications :

Western Blot: 0.5-1.5 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). [UniProt]

Immunogen :

Synthetic peptide sequence (RECOMBINANT) corresponding to the N-terminus amino acids of TNKS

Format :

Liquid

Applications w/Dilutions :

Western Blot: 0.5-1.5 ug/mL

Aliases :

4930554K12Rik; ADP-ribosyltransferase diphtheria toxin-like 5; AI662855; ARTD5; C86528; D130072O21Rik; HGNC:11941; LOW QUALITY PROTEIN: tankyrase-1; mTNKS1; PARP5A; PARP-5a; PARPL; pART5; Poly [ADP-ribose] polymerase 5A; Poly [ADP-ribose] polymerase tankyrase-1; poly [ADP-ribose] polymerase tankyrase-1; tankyrase-1; Protein poly-ADP-ribosyltransferase tankyrase-1; TANK1; tankyrase; tankyrase 1; tankyrase I; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; tankyrase-1; TIN1; TINF1; TNKS; TNKS1; TNKS-1; TRF1-interacting ankyrin-related ADP-ribose polymerase; TRF1-interacting ankyrin-related ADP-ribose polymerase 1