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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-AMPK alpha-1,2 (Thr183, Thr172) Polyclonal Antibody
catalog :
PA5-17831
quantity :
100 uL
price :
US 514.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
Invitrogen product webpage
citations: 14
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 6a
Mlyczynska E, Kurowska P, Drwal E, Opydo Chanek M, Tworzydło W, Kotula Balak M, et al. Apelin and apelin receptor in human placenta: Expression, signalling pathway and regulation of trophoblast JEG‑3 and BeWo cells proliferation and cell cycle. Int J Mol Med. 2020;45:691-702 pubmed publisher
Apaydin T, Zonis S, Zhou C, Valencia C, Barrett R, Strous G, et al. WIP1 is a novel specific target for growth hormone action. iScience. 2023;26:108117 pubmed publisher
Tao Z, Lin R, Zhang R, He P, Lei C, Li Y. Ischemia reperfusion myocardium injuries in type 2 diabetic rats: Effects of ketamine and insulin on LC3-II and mTOR expression. Int J Immunopathol Pharmacol. 2023;37:3946320231196450 pubmed publisher
Jiang W, Song J, Zhang S, Ye Y, Wang J, Zhang Y. CTRP13 Protects H9c2 Cells Against Hypoxia/Reoxygenation (H/R)-Induced Injury Via Regulating the AMPK/Nrf2/ARE Signaling Pathway. Cell Transplant. 2021;30:9636897211033275 pubmed publisher
Yao Q, Li H, Fan L, Huang S, Wang J, Zheng N. The combination of lactoferrin and linolenic acid inhibits colorectal tumor growth through activating AMPK/JNK-related apoptosis pathway. Peerj. 2021;9:e11072 pubmed publisher
Becherini P, Caffa I, Piacente F, Damonte P, Vellone V, Passalacqua M, et al. SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice. Cancer Metab. 2021;9:6 pubmed publisher
Kurowska P, Mlyczynska E, Estienne A, Barbe A, Rajska I, Soból K, et al. Expression and Impact of Vaspin on In Vitro Oocyte Maturation through MAP3/1 and PRKAA1 Signalling Pathways. Int J Mol Sci. 2020;21: pubmed publisher
Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, et al. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 2020;583:620-624 pubmed publisher
Gordillo G, Biswas A, Singh K, Sen A, Guda P, Miller C, et al. Mitochondria as Target for Tumor Management of Hemangioendothelioma. Antioxid Redox Signal. 2020;: pubmed publisher
Nagappan A, Kim J, Jung D, Jung M. Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways. Int J Mol Sci. 2019;21: pubmed publisher
Ding D, Jia Y, Zhang B, Guan C, Zhou S, Li X, et al. C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling. Mol Med Rep. 2019;20:5091-5099 pubmed publisher
Saladini S, Aventaggiato M, Barreca F, Morgante E, Sansone L, Russo M, et al. Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells. Cells. 2019;8: pubmed publisher
Zhai Z, Keereetaweep J, Liu H, Feil R, Lunn J, Shanklin J. Trehalose 6-Phosphate Positively Regulates Fatty Acid Synthesis by Stabilizing WRINKLED1. Plant Cell. 2018;30:2616-2627 pubmed publisher
Nagappan A, Jung D, Kim J, Lee H, Jung M. Gomisin N Alleviates Ethanol-Induced Liver Injury through Ameliorating Lipid Metabolism and Oxidative Stress. Int J Mol Sci. 2018;19: pubmed publisher
product information
Product Type :
Antibody
Product Name :
Phospho-AMPK alpha-1,2 (Thr183, Thr172) Polyclonal Antibody
Catalog # :
PA5-17831
Quantity :
100 uL
Price :
US 514.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Non-human primate, Rat
Applications :
Western Blot: 1:1,000
Species :
Human, Mouse, Non-human primate, Rat
Isotype :
IgG
Storage :
-20 C
Description :
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Immunogen :
Synthetic phosphopeptides corresponding to residues surrounding Thr183 of human AMPKa 1 and Thr172 of AMPKa 2
Format :
Liquid
Applications w/Dilutions :
Western Blot: 1:1,000
Aliases :
2310008I11Rik; 5'-AMP-activated protein kinase alpha-1 catalytic subunit; 5'-AMP-activated protein kinase alpha-2 catalytic subunit; 5'-AMP-activated protein kinase catalytic alpha-2 subunit; 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; 63 kDa subunit; A830082D05; AAPK2; ACACA kinase; acetyl-CoA carboxylase kinase; AI194361; AI450832; AL024255; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase; AMP-activated protein kinase alpha 2; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; AMP-activated protein kinase alpha-2 variant B; AMP-activated protein kinase, alpha 1 catalytic subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK; AMPK 63 kDa subunit; AMPK alpha 1; AMPK alpha 2; AMPK alpha-1 chain; AMPK alpha-2 chain; AMPK subunit alpha-1; AMPK subunit alpha-2; AMPK1; AMPK2; AMPKa1; AMPKa2; AMPK-activated protein kinase alpha-2 subunit; AMPKalpha1; AMPK-alpha-1 chain; AMPKalpha2; AMPK-alpha-2 chain; C130083N04Rik; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; pAMPK; PRKAA; Prkaa1; Prkaa2; protein kinase; protein kinase AMP-activated alpha 2 catalytic subunit; protein kinase AMP-activated catalytic subunit alpha 1; protein kinase AMP-activated catalytic subunit alpha 2; protein kinase, AMP-activated, alpha 1 catalytic subunit; protein kinase, AMP-activated, alpha 2 catalytic subunit; tau-protein kinase PRKAA1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA