Phospho-IkB epsilon (Ser18, Ser22) Polyclonal Antibody | Invitrogen PA5-17532 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-IkB epsilon (Ser18, Ser22) Polyclonal Antibody

catalog :

PA5-17532

quantity :

100µL

price :

330 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat, dog, cow

application :

western blot

product information

Product Type :

Antibody

Product Name :

Phospho-IkB epsilon (Ser18, Ser22) Polyclonal Antibody

Catalog # :

PA5-17532

Quantity :

100µL

Price :

330 USD

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Canine, Human, Mouse, Rat

Applications :

Western Blot: 1:1000

Species :

Bovine, Canine, Human, Mouse, Rat

Isotype :

IgG

Storage :

-20°C

Description :

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT (see STAT6, MIM 601512), AP1 (JUN, MIM 165160), and NFAT (see NFATC1, MIM 600489).

Immunogen :

Synthetic phosphopeptide corresponding to residues surrounding serine 18/22 of human IkB epsilon

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1000

Aliases :

I-kappa-B-epsilon; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; ikB-E; ikB-epsilon; ikappaBepsilon