This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
4E-BP2 Polyclonal Antibody
catalog :
PA5-17527
quantity :
100 uL
price :
US 404.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, bovine
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
4E-BP2 Polyclonal Antibody
Catalog # :
PA5-17527
Quantity :
100 uL
Price :
US 404.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Bovine, Human, Mouse, Non-human primate, Rat
Applications :
Immunohistochemistry (Paraffin): 1:200-1:800, Immunoprecipitation: 1:100, Western Blot: 1:1,000
Species :
Bovine, Human, Mouse, Non-human primate, Rat
Isotype :
IgG
Storage :
-20 C
Description :
PHAS-II (eIF4E-binding protein II) is involved in translation initiation. PHAS-II is highest in liver and kidney. PHAS proteins bind to eIF-4E, the mRNA cap-binding protein, and inhibit translation of capped mRNA in vitro and in cells. Phosphorylation in the appropriate site(s) promotes dissociation of PHAS/eIF-4E complexes. This allows eIF-4E to bind to eIF-4G (p220), thereby increasing the amount of the eIF-4F complex and the rate of translation initiation. Pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway is involved in the control of PHAS-I and -II. Thus, PHAS proteins may be mediators of the effects of this pathway on protein synthesis and cell proliferation.
Immunogen :
Synthetic peptide corresponding to residues at the carboxy-terminus of human 4E-BP2
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 1:200-1:800, Immunoprecipitation: 1:100, Western Blot: 1:1,000
Aliases :
2810011I19Rik; 4EBP2; 4E-BP2; AA792569; BC010348; eIF4E-binding protein 2; EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2; eukaryotic translation initiation factor 4E-binding protein 2; PHASII; PHAS-II; Phosphorylated heat- and acid-stable protein regulated by insulin 2; phosphorylated, heat and acid stable regulated by insulin protein II
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA