NEDD4 Polyclonal Antibody | Invitrogen PA5-17463 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NEDD4 Polyclonal Antibody

catalog :

PA5-17463

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 7e immunoprecipitation; human; 1:100; loading ...; fig 2b immunohistochemistry; human; 1:100; loading ...; fig 7e western blot; human; 1:1000; loading ...; fig 2b, 4f	Yang Y, Luo M, Zhang K, Zhang J, Gao T, Connell D, et al. Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma. Nat Commun. 2020;11:433 pubmed publisher
	Cheng Z, Stefani C, Skillman T, Klimas A, Lee A, DiBernardo E, et al. MicroMagnify: A Multiplexed Expansion Microscopy Method for Pathogens and Infected Tissues. Adv Sci (Weinh). 2023;10:e2302249 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NEDD4 Polyclonal Antibody

Catalog # :

PA5-17463

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

Immunocytochemistry: 1:50, Western Blot: 1:1,000

Species :

Human, Mouse, Non-human primate, Rat

Isotype :

IgG

Storage :

-20 C

Description :

The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.

Immunogen :

Synthetic peptide corresponding to human NEDD4 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50, Western Blot: 1:1,000

Aliases :

AA959633; AL023035; AU019897; cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; E430025J12Rik; HECT-type E3 ubiquitin transferase NEDD4; Kiaa0093; mKIAA0093; NEDD4; NEDD-4; NEDD4 E3 ubiquitin protein ligase; Nedd4-1; Nedd4a; Neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated 4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated gene 4a; neural precursor cell expressed, developmentally down-regulted gene 4; OTTHUMP00000217840; OTTHUMP00000217841; OTTHUMP00000217842; PIG53; receptor-potentiating factor 1; RPF1

more info or order :

Invitrogen product webpage