ZFP36L1/ZFP36L2 Polyclonal Antibody | Invitrogen PA5-17364 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZFP36L1/ZFP36L2 Polyclonal Antibody

catalog :

PA5-17364

quantity :

100µL

price :

US 305

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken, bovine

application :

western blot

product information

Product Type :

Antibody

Product Name :

ZFP36L1/ZFP36L2 Polyclonal Antibody

Catalog # :

PA5-17364

Quantity :

100µL

Price :

US 305

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Chicken, Human, Mouse, Non-human primate, Rat

Applications :

Western Blot: 1:1000

Species :

Bovine, Chicken, Human, Mouse, Non-human primate, Rat

Isotype :

IgG

Storage :

-20°C

Description :

Butyrate response factor 1 (BRF1; also known as EGF response factor 1 [ERF1], TIS11B, ZFP36L1) and butyrate response factor 2 (BRF2; also known as EGF response factor 2 [ERF2], TIS11D, ZFP36L2) both belong to the TIS11 family of CCCH zinc-finger proteins. This family of proteins, which also includes tristetraprolin (TTP), bind to AU-rich elements (ARE) found in the 3'-untranslated regions of mRNAs and promote de-adenylation and rapid degradation by the exosome. These proteins play a critical role in cell growth control by regulating the mRNA turnover of multiple cytokines, growth factors and cell cycle regulators, including GM-CSF, TNF , IL-2, IL-3 and IL-6. Deregulated ARE-mRNA stability can contribute to both inflammation and oncogenic transformation (6-8). Insulin-induced stabilization of ARE-containing transcripts is mediated by Akt/PKB phosphorylation of BRF1 at Ser92, which results in binding by 14-3-3 protein and inactivation of BRF1.

Immunogen :

Synthetic peptide corresponding to the carboxy terminus of human BRF1 protein

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1000

Aliases :

AW742437; AW743212; BERG36; BOS_11072; BOS_11576; BRF1; BRF2; Butyrate response factor 1; Butyrate response factor 2; Cmg1; D530020L18Rik; early response factor Berg36; EGF-inducible protein CMG1; EGF-response factor 1; EGF-response factor 2; ERF1; ERF-1; ERF2; ERF-2; mRNA decay activator protein ZFP36L1; mRNA decay activator protein ZFP36L2; RNF162B; RNF162C; Tis11b; TIS11D; TPA-induced sequence 11b; TPA-induced sequence 11d; ZFP36 ring finger protein like 1; ZFP36 ring finger protein like 2; ZFP36 ring finger protein-like 1; ZFP36 ring finger protein-like 2; Zfp36l1; ZFP36L2; ZFP36-like 1; ZFP36-like 2; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H type-like 2; zinc finger protein 36, C3H type-like 2-like; Zinc finger protein 36, C3H1 type-like 1; Zinc finger protein 36, C3H1 type-like 2; zinc finger protein, C3H type, 36-like 1; zinc finger protein, C3H type, 36-like 2