EEA1 Polyclonal Antibody | Invitrogen PA5-17228 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

EEA1 Polyclonal Antibody

catalog :

PA5-17228

quantity :

100 uL

price :

US 486.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 7

Reference
Byrnes A, Dominguez S, Yen C, Laufer B, Foreman O, Reichelt M, et al. Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection. Mol Ther Nucleic Acids. 2023;32:773-793 pubmed publisher
McLean J, Wilson J, Tian T, Watson J, VanHart M, Bean A, et al. Disruption of Endosomal Sorting in Schwann Cells Leads to Defective Myelination and Endosomal Abnormalities Observed in Charcot-Marie-Tooth Disease. J Neurosci. 2022;42:5085-5101 pubmed publisher
Joly J, Hudik E, Lécart S, Roos D, Verkuijlen P, Wrona D, et al. Membrane Dynamics and Organization of the Phagocyte NADPH Oxidase in PLB-985 Cells. Front Cell Dev Biol. 2020;8:608600 pubmed publisher
Gireud Goss M, Reyes S, Tewari R, Patrizz A, Howe M, Kofler J, et al. The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion. Mol Cell Neurosci. 2020;108:103542 pubmed publisher
Markworth R, Adolfs Y, Dambeck V, Steinbeck L, Lizé M, Pasterkamp R, et al. Sensory axon growth requires spatiotemporal integration of CaSR and TrkB signalling. J Neurosci. 2019;: pubmed publisher
Gireud Goss M, Reyes S, Wilson M, Farley M, Memarzadeh K, Srinivasan S, et al. Distinct mechanisms enable inward or outward budding from late endosomes/multivesicular bodies. Exp Cell Res. 2018;372:1-15 pubmed publisher
Burk K, Murdoch J, Freytag S, Koenig M, Bharat V, Markworth R, et al. EndophilinAs regulate endosomal sorting of BDNF-TrkB to mediate survival signaling in hippocampal neurons. Sci Rep. 2017;7:2149 pubmed publisher

product information

Product Type :

Antibody

Product Name :

EEA1 Polyclonal Antibody

Catalog # :

PA5-17228

Quantity :

100 uL

Price :

US 486.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

Immunocytochemistry: 1:100, Immunoprecipitation: 1:25, Western Blot: 1:1,000

Species :

Human, Mouse, Non-human primate, Rat

Isotype :

IgG

Storage :

-20 C

Description :

Early endosomal antigen 1 (EEA1) is a 162 kDa membrane bound protein component specific to the early endosome and is essential for fusion between early endocytic vesicles. Early endosomes are cytoplasmic compartments which fuse with endocytic vesicles for redistribution of extracellular compounds to alternate destinations. Zinc-finger-like domains, reminiscent of those found in nucleic acid binding proteins, are located in the amino and carboxyl-terminal domains of EEA1. The carboxyl-terminal zinc-finger-like-domain is conserved in several other non-nuclear proteins, some of which are also involved in intracellular protein trafficking. In addition, this domain is an authentic zinc-binding domain and is critical to the intracellular localization of EEA1. Membrane association of EEA1 has been shown dependent on phosphatidyl 3-kinase activity, inhibitors of which cause EEA1 to dissociate from early endosomes.

Immunogen :

Synthetic peptide corresponding to residues surrounding Gly14 of human EEA1 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunoprecipitation: 1:25, Western Blot: 1:1,000

Aliases :

A430109M19Rik; B230358H09Rik; Early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; EEA1; Endosome-associated protein p162; MST105; MSTP105; ZFYVE2; Zinc finger FYVE domain-containing protein 2