GLT-1 Polyclonal Antibody | Invitrogen PA5-17099 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GLT-1 Polyclonal Antibody

catalog :

PA5-17099

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

citations: 4

Reference
Rojas F, Aguilar R, Almeida S, Fritz E, Corval xe1 n D, Ampuero E, et al. Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons. Front Cell Dev Biol. 2023;11:1226604 pubmed publisher
Celli R, Striano P, Citraro R, Di Menna L, Cannella M, Imbriglio T, et al. mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data. Curr Neuropharmacol. 2023;21:105-118 pubmed publisher
Stergachis A, Pujol Giménez J, Gyimesi G, Fuster D, Albano G, Troxler M, et al. Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism. Ann Neurol. 2019;85:921-926 pubmed publisher
Simonin A, Montalbetti N, Gyimesi G, Pujol GimÃ©nez J, Hediger M. The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2. J Biol Chem. 2015;290:30464-74 pubmed publisher

product information

Product Type :

Antibody

Product Name :

GLT-1 Polyclonal Antibody

Catalog # :

PA5-17099

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.

Immunogen :

Synthetic peptide corresponding to human EAAT2

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

1700091C19Rik; 2900019G14Rik; AI159670; Eaat2; EAAT2 variant mEAAT2/5UT5; excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; glial high affinity glutamate transporter; Glt; GLT1; GLT-1; GLT1a; GLT1b; GLT1c; glutamate transporter 1c; glutamate/aspartate transporter II; GLUT-R; HBGT; high affinity glucose transporter; MGLT1; OTTHUMP00000165209; OTTHUMP00000165210; SLC1A2; Sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; solute carrier family 1 member 2; solute carrier family 1, member 2