ADAM17 Polyclonal Antibody | Invitrogen PA5-17079 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ADAM17 Polyclonal Antibody

catalog :

PA5-17079

quantity :

100 uL

price :

US 400.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a western blot; human; 1:500; loading ...; fig 2c, 2f	Van Meenen D, Doege A, Alefeld E, Haase A, Beier M, Kiefer T, et al. ADAM10 and ADAM17-Novel Players in Retinoblastoma Carcinogenesis. Int J Mol Sci. 2022;23: pubmed publisher

product information

Product Type :

Antibody

Product Name :

ADAM17 Polyclonal Antibody

Catalog # :

PA5-17079

Quantity :

100 uL

Price :

US 400.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Non-human primate

Applications :

Immunocytochemistry: 5 ug/mL, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Species :

Human, Non-human primate

Isotype :

IgG

Storage :

-20 C

Description :

ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane bound precusor of TNF-alpha to its mature soluble form. ADAM 17 is responsbile for the proteolytical release of soluble JAM3 from endothelial cells surface and the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and the amyloid precursor protein. It acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.

Immunogen :

Synthetic peptide corresponding to amino acids surrounding Val200 of human TACE

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 ug/mL, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Aliases :

a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADAM; ADAM 17; ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 18; Adam17; ADAM18; ADAMs; CD156B; CD156b antigen; CSVP; Disintegrin and metalloproteinase domain-containing protein 17; metalloendopeptidases; NISBD; NISBD1; Snake venom-like protease; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme

more info or order :

Invitrogen product webpage