SIRT1 Polyclonal Antibody | Invitrogen PA5-17074 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SIRT1 Polyclonal Antibody

catalog :

PA5-17074

quantity :

100 uL

price :

US 460.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500; loading ...; fig 4e	Gong K, Qu B, Liao D, Liu D, Wang C, Zhou J, et al. MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor ?/?-dependent manner. Biochem Biophys Res Commun. 2016;478:260-267 pubmed publisher
immunoprecipitation; human; 1:500; loading ...; fig 4c western blot; human; 1:500; loading ...; fig 4c	Qu B, Ma Y, Yan M, Gong K, Liang F, Deng S, et al. Sirtuin1 promotes osteogenic differentiation through downregulation of peroxisome proliferator-activated receptor ? in MC3T3-E1 cells. Biochem Biophys Res Commun. 2016;478:439-445 pubmed publisher
	El Maraghy S, Reda A, Essam R, Kortam M. The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism. Inflammopharmacology. 2023;31:2701-2717 pubmed publisher
	Farini A, Tripodi L, Villa C, Strati F, Facoetti A, Baselli G, et al. Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin-deficient mice. EMBO Mol Med. 2023;15:e16244 pubmed publisher
	Scrimieri R, Cazzaniga A, Castiglioni S, Maier J. Vitamin D Prevents High Glucose-Induced Lipid Droplets Accumulation in Cultured Endothelial Cells: The Role of Thioredoxin Interacting Protein. Biomedicines. 2021;9: pubmed publisher
	Aljaylani A, Fluitt M, Piselli A, Shepard B, Tiwari S, Ecelbarger C. Acid Loading Unmasks Glucose Homeostatic Instability in Proximal-Tubule-Targeted Insulin/Insulin-Like-Growth-Factor-1 Receptor Dual Knockout Mice. Cell Physiol Biochem. 2020;54:682-695 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SIRT1 Polyclonal Antibody

Catalog # :

PA5-17074

Quantity :

100 uL

Price :

US 460.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Mouse

Applications :

Immunoprecipitation: 1:50, Western Blot: 1:1,000

Species :

Mouse

Isotype :

IgG

Storage :

-20 C

Description :

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).

Immunogen :

Synthetic peptide corresponding to the carboxy terminus of mouse SirT1

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: 1:50, Western Blot: 1:1,000

Aliases :

75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2; Sir2a; SIR2alpha; SIR2L1; sir2-like 1; SIR2-like protein 1; SIRT 1; SIRT1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1

more info or order :

Invitrogen product webpage