This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Desmin Polyclonal Antibody
catalog :
PA5-16705
quantity :
1 mL
price :
US 489
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 17
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1d
Langdon C, Gadek K, Garcia M, Evans M, Reed K, Bush M, et al. Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity. Nat Commun. 2021;12:5520 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 7d
Rosenthal S, Liu X, Ganguly S, Dhar D, Pasillas M, Ricciardelli E, et al. Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology. 2021;74:667-685 pubmed publisher
  • immunohistochemistry; mouse
  • immunohistochemistry - paraffin section; human; loading ...; fig s4
Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, et al. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017;127:1254-1270 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; tbl 1
Begam M, Abro V, Mueller A, Roche J. Sodium 4-phenylbutyrate reduces myofiber damage in a mouse model of Duchenne muscular dystrophy. Appl Physiol Nutr Metab. 2016;41:1108-1111 pubmed
  • immunohistochemistry; human; 1:50; loading ...; fig s9d
Hyslop L, Blakeley P, Craven L, Richardson J, Fogarty N, Fragouli E, et al. Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease. Nature. 2016;534:383-6 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 1g
Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, et al. Tumour resistance in induced pluripotent stem cells derived from naked mole-rats. Nat Commun. 2016;7:11471 pubmed publisher
Kinney C, O Neill A, Noland K, Huang W, Muriel J, Lukyanenko V, et al. μ-Crystallin in Mouse Skeletal Muscle Promotes a Shift from Glycolytic toward Oxidative Metabolism. Curr Res Physiol. 2021;4:47-59 pubmed publisher
Tang J, Ju A, Li B, Zhang S, Gong Y, Ma B, et al. Young and Undamaged rMSA Improves the Healthspan and Lifespan of Mice. Biomolecules. 2021;11: pubmed publisher
Scarborough E, Uchida K, Vogel M, Erlitzki N, Iyer M, Phyo S, et al. Microtubules orchestrate local translation to enable cardiac growth. Nat Commun. 2021;12:1547 pubmed publisher
Badu Mensah A, Guo X, McAleer C, Rumsey J, Hickman J. Functional skeletal muscle model derived from SOD1-mutant ALS patient iPSCs recapitulates hallmarks of disease progression. Sci Rep. 2020;10:14302 pubmed publisher
Lu A, Guo P, Wang L, Tseng C, Huard M, Allen C, et al. Heterogenetic parabiosis between healthy and dystrophic mice improve the histopathology in muscular dystrophy. Sci Rep. 2020;10:7075 pubmed publisher
Aung Htut M, Ham K, Tchan M, Johnsen R, Schnell F, Fletcher S, et al. Splice modulating antisense oligonucleotides restore some acid-alpha-glucosidase activity in cells derived from patients with late-onset Pompe disease. Sci Rep. 2020;10:6702 pubmed publisher
Frew J, Baradaran Heravi A, Balgi A, Wu X, Yan T, Arns S, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020;15:21 pubmed publisher
Amini Nik S, Sadri A, Diao L, Belo C, Jeschke M. Accumulation of myeloid lineage cells is mapping out liver fibrosis post injury: a targetable lesion using Ketanserin. Exp Mol Med. 2018;50:81 pubmed publisher
Ackermann M, Petrosino J, Manring H, Wright P, Shettigar V, Kilic A, et al. TGF-β1 affects cell-cell adhesion in the heart in an NCAM1-dependent mechanism. J Mol Cell Cardiol. 2017;112:49-57 pubmed publisher
Mu X, Español Suñer R, Mederacke I, Affò S, Manco R, Sempoux C, et al. Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment. J Clin Invest. 2015;125:3891-903 pubmed publisher
Kasuya J, Sudo R, Masuda G, Mitaka T, Ikeda M, Tanishita K. Reconstruction of hepatic stellate cell-incorporated liver capillary structures in small hepatocyte tri-culture using microporous membranes. J Tissue Eng Regen Med. 2015;9:247-56 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Desmin Polyclonal Antibody
Catalog # :
PA5-16705
Quantity :
1 mL
Price :
US 489
Clonality :
Polyclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:4,000-1:5,000
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
Immunogen :
A synthetic peptide mapping near the C-terminus of human desmin
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:4,000-1:5,000
Aliases :
CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA