product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD20 Polyclonal Antibody
catalog :
PA5-16701
quantity :
500 uL
price :
US 514.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, dogs, pigs , cat, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; rhesus macaque; loading ...; fig s6f
He X, Chandrashekar A, Zahn R, Wegmann F, Yu J, Mercado N, et al. Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques. Cell. 2021;184:3467-3473.e11 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 6d
Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s6b
Gehrig J, Venkatesh S, Chang H, Hibberd M, Kung V, Cheng J, et al. Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. Science. 2019;365: pubmed publisher
  • immunohistochemistry - frozen section; pigs ; 1:500; fig 5
Dahan N, Sarig U, Bronshtein T, Baruch L, Karram T, Hoffman A, et al. Dynamic Autologous Reendothelialization of Small-Caliber Arterial Extracellular Matrix: A Preclinical Large Animal Study. Tissue Eng Part A. 2017;23:69-79 pubmed publisher
  • immunohistochemistry - paraffin section; dogs; 1:400; fig 5
Mizutani N, Goto Koshino Y, Takahashi M, Uchida K, Tsujimoto H. Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma. J Vet Med Sci. 2016;78:1237-44 pubmed publisher
  • immunohistochemistry - paraffin section; dogs; 1:400; fig 2
Mizutani N, Goto Koshino Y, Tsuboi M, Kagawa Y, Ohno K, Uchida K, et al. Evaluation of CD25-positive cells in relation to the subtypes and prognoses in various lymphoid tumours in dogs. Vet Immunol Immunopathol. 2016;173:39-43 pubmed publisher
  • immunohistochemistry - paraffin section; cat; 1:300; fig 4
Arzi B, Mills Ko E, Verstraete F, Kol A, Walker N, Badgley M, et al. Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats. Stem Cells Transl Med. 2016;5:75-86 pubmed publisher
Jager M, Choi E, Tomlinson J, Van de Walle G. Naturally acquired equine parvovirus-hepatitis is associated with a wide range of hepatic lesions in horses. Vet Pathol. 2024;61:442-452 pubmed publisher
Kurokawa A, Yamamoto Y. Immunohistochemical identification of T and B lymphocytes in formalin-fixed, paraffin-embedded tissues of 53 avian species using commercial antibodies. J Vet Med Sci. 2023;85:1121-1130 pubmed publisher
Hordeaux J, Ramezani A, Tuske S, Mehta N, Song C, Lynch A, et al. Immune transgene-dependent myocarditis in macaques after systemic administration of adeno-associated virus expressing human acid alpha-glucosidase. Front Immunol. 2023;14:1094279 pubmed publisher
Ng K, Beatty J, Tse M, Giuliano A. Nasal Lymphoma with Low Mitotic Index in Three Cats Treated with Chlorambucil and Prednisolone. Vet Sci. 2022;9: pubmed publisher
Abdelrahman S, Abdelfatah M, Keshta A. Rapamycin-filgrastim combination therapy ameliorates portal hypertension-induced splenomegaly: Role of β actin and S100A9 proteins modulation. Iran J Basic Med Sci. 2022;25:732-744 pubmed publisher
Ma J, Guillot A, Yang Z, Mackowiak B, Hwang S, Park O, et al. Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure. J Clin Invest. 2022;132: pubmed publisher
Wang S, Liu M, Li X, Zhang J, Wang F, Zhang C, et al. Canonical and noncanonical regulatory roles for JAK2 in the pathogenesis of rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis. FASEB J. 2022;36:e22336 pubmed publisher
Rissi D, McHale B, Miller A. Primary nervous system lymphoma in cats. J Vet Diagn Invest. 2022;34:712-717 pubmed publisher
Tricarico D, Convertino A, Mehmeti I, Ranieri G, Leonetti F, Laface C, et al. Inflammatory Related Reactions in Humans and in Canine Breast Cancers, A Spontaneous Animal Model of Disease. Front Pharmacol. 2022;13:752098 pubmed publisher
Song Z, Bao L, Deng W, Liu J, Ren E, Lv Q, et al. Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients. Signal Transduct Target Ther. 2022;7:29 pubmed publisher
Powell G, Pavlovic Djuranovic S, Djuranovic S. Gene dosage effects of poly(A) track-engineered hypomorphs. Mol Ther Nucleic Acids. 2021;26:865-878 pubmed publisher
Matsumoto F, Shima Sawa M, Furusawa Y, Yamato O, Yabuki A. A rapid multiple immunofluorescence method for the simultaneous detection of CD20 and CD3 in canine and feline cytological samples. J Vet Med Sci. 2021;83:832-836 pubmed publisher
Quintavalla F, Di Lecce R, Carlini D, Zanfabro M, Cantoni A. Multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat. JFMS Open Rep. 2020;6:2055116920972077 pubmed publisher
Yoon S, Kim M, Paeng K, Yu K, Lee C, Song Y, et al. Efficacy of Local Minocycline Agents in Treating Peri-Implantitis: An Experimental In Vivo Study in Beagle Dogs. Pharmaceutics. 2020;12: pubmed publisher
Martínez I, Perez Martinez C, Salinas L, Juste R, Marin J, Balseiro A. Phenotypic Characterization of Encephalitis and Immune Response in the Brains of Lambs Experimentally Infected with Spanish Goat Encephalitis Virus. Animals (Basel). 2020;10: pubmed publisher
Stamilla A, Messina A, Condorelli L, Licitra F, Antoci F, Lanza M, et al. Morphological and Immunohistochemical Examination of Lymphoproliferative Lesions Caused by Marek's Disease Virus in Breeder Chickens. Animals (Basel). 2020;10: pubmed publisher
Yoon S, Kim M, Paeng K, Yu K, Lee C, Song Y, et al. Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study. Pharmaceutics. 2020;12: pubmed publisher
Iba M, Kim C, Sallin M, Kwon S, Verma A, OVERK C, et al. Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models. J Neuroinflammation. 2020;17:214 pubmed publisher
Martínez I, Oleaga A, Sojo I, García Iglesias M, Perez Martinez C, García Marín J, et al. Immunohistochemical Assessment of Immune Response in the Dermis of Sarcoptes scabiei-Infested Wild Carnivores (Wolf and Fox) and Ruminants (Chamois and Red Deer). Animals (Basel). 2020;10: pubmed publisher
Blanco Vázquez C, Prieto M, Barral M, Juste R, Lesellier S, Salguero F, et al. Local Lung Immune Response to Mycobacterium bovis Challenge after BCG and M. bovis Heat-Inactivated Vaccination in European Badger (Meles meles). Pathogens. 2020;9: pubmed publisher
Martin K, Junker U, Tritto E, Sutter E, Rubic Schneider T, Morgan H, et al. Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology. Front Immunol. 2020;11:745 pubmed publisher
Jimenez M, Stoore C, Hidalgo C, Corrêa F, Hernandez M, Benavides J, et al. Lymphocyte Populations in the Adventitial Layer of Hydatid Cysts in Cattle: Relationship With Cyst Fertility Status and Fasciola Hepatica Co-Infection. Vet Pathol. 2020;57:108-114 pubmed publisher
Sajiki Y, Konnai S, Okagawa T, Nishimori A, Maekawa N, Goto S, et al. Prostaglandin E2-Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection. J Immunol. 2019;203:1313-1324 pubmed publisher
Hordeaux J, Hinderer C, Goode T, Katz N, Buza E, Bell P, et al. Toxicology Study of Intra-Cisterna Magna Adeno-Associated Virus 9 Expressing Human Alpha-L-Iduronidase in Rhesus Macaques. Mol Ther Methods Clin Dev. 2018;10:79-88 pubmed publisher
Hordeaux J, Hinderer C, Goode T, Buza E, Bell P, Calcedo R, et al. Toxicology Study of Intra-Cisterna Magna Adeno-Associated Virus 9 Expressing Iduronate-2-Sulfatase in Rhesus Macaques. Mol Ther Methods Clin Dev. 2018;10:68-78 pubmed publisher
Vallejo R, García Marín J, Juste R, Muñoz Mendoza M, Salguero F, Balseiro A. Immunohistochemical characterization of tuberculous lesions in sheep naturally infected with Mycobacterium bovis. BMC Vet Res. 2018;14:154 pubmed publisher
Renshaw R, Griffing J, Weisman J, Crofton L, Laverack M, Poston R, et al. Characterization of a Vesivirus Associated with an Outbreak of Acute Hemorrhagic Gastroenteritis in Domestic Dogs. J Clin Microbiol. 2018;56: pubmed publisher
Vogel M, Weigand J, Kluge B, Grez M, Suess B. A small, portable RNA device for the control of exon skipping in mammalian cells. Nucleic Acids Res. 2018;46:e48 pubmed publisher
Hinderer C, Katz N, Buza E, Dyer C, Goode T, Bell P, et al. Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN. Hum Gene Ther. 2018;29:285-298 pubmed publisher
Kim A, Chung J, Akilesh S, Koziell A, Jain S, Hodgin J, et al. B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement. JCI Insight. 2017;2: pubmed publisher
Li J, Davidson D, Martins Souza C, Zhong M, Wu N, Park M, et al. Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition. Mol Cell Biol. 2015;35:4069-82 pubmed publisher
Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, et al. ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling. Nat Commun. 2015;6:5794 pubmed publisher
Aung L, Mouradian M, Dhib Jalbut S, BALASHOV K. MMP-9 expression is increased in B lymphocytes during multiple sclerosis exacerbation and is regulated by microRNA-320a. J Neuroimmunol. 2015;278:185-9 pubmed publisher
Aresu L, Martini V, Rossi F, Vignoli M, Sampaolo M, Aricò A, et al. Canine indolent and aggressive lymphoma: clinical spectrum with histologic correlation. Vet Comp Oncol. 2015;13:348-62 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD20 Polyclonal Antibody
Catalog # :
PA5-16701
Quantity :
500 uL
Price :
US 514.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Canine, Feline, Human, Mouse
Applications :
Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:300, Western Blot: 1:2,000
Species :
Canine, Feline, Human, Mouse
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
CD20 is a non-glycosylated surface phosphoprotein that has a molecular weight range of 33-37 kDa depending on the degree of phosphorylation. CD20 is expressed on mature and most malignant B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B-cell proliferation. CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following monoclonal antibody treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
Immunogen :
Synthetic peptide derived from C-terminus of human CD20 protein
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:300, Western Blot: 1:2,000
Aliases :
AA960661; APY; ATOPY; B1; B-cell differentiation antigen Ly-44; B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; Bp35; Cd20; CD20 antigen; CD20 cell surface protein; CD20 receptor; CVID5; EGK_06167; Fc epsilon receptor I beta chain; Fc Fragment of IgE high affinity I receptor for beta polypeptide; FCER1B; High affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; IGEL; IGER; IGHER; LEU16; LEU-16; Leukocyte surface antigen Leu-16; Ly44; Ly-44; Lymphocyte antigen 44; membrane spanning 4-domains A1; membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; MGC3969; MS4A1; MS4A2; S7
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA