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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Myeloperoxidase Polyclonal Antibody
catalog :
PA5-16672
quantity :
500 uL
price :
US 460.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 73
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:1000; loading ...; fig 5d
Tian Y, Qu S, Alam H, Williams A, Wu Z, Deng Q, et al. Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis. JCI Insight. 2020;5: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s1
Asare Y, Koehncke J, Selle J, Simsekyilmaz S, Jankowski J, Shagdarsuren G, et al. Differential Role for Activating FcγRIII in Neointima Formation After Arterial Injury and Diet-Induced Chronic Atherosclerosis in Apolipoprotein E-Deficient Mice. Front Physiol. 2020;11:673 pubmed publisher
  • immunohistochemistry; rat; 1:500
Sun J, Wang Z, Wang X. Suppression of LRRC19 promotes cutaneous wound healing in pressure ulcers in mice. Organogenesis. 2018;14:13-24 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s10a
Xue X, Bredell B, Anderson E, Martin A, Mays C, Nagao Kitamoto H, et al. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A. 2017;114:E9608-E9617 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300
von Laffert M, Hänel M, Dietel M, Anagnostopoulos I, Johrens K. Increase of T and B cells and altered BACH2 expression patterns in bone marrow trephines of imatinib-treated patients with chronic myelogenous leukaemia. Oncol Lett. 2016;12:2421-2428 pubmed
  • immunohistochemistry - paraffin section; mouse; fig 4
Akashi K, Saegusa J, Sendo S, Nishimura K, Okano T, Yagi K, et al. Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice. Arthritis Res Ther. 2016;18:113 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; fig 4
Allaire J, Roy S, Ouellet C, Lemieux Ã, Jones C, Paquet M, et al. Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation. Int J Cancer. 2016;138:2700-12 pubmed publisher
  • western blot; rat
Peiffer D, Wang L, Zimmerman N, Ransom B, Carmella S, Kuo C, et al. Dietary Consumption of Black Raspberries or Their Anthocyanin Constituents Alters Innate Immune Cell Trafficking in Esophageal Cancer. Cancer Immunol Res. 2016;4:72-82 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig s4
Dimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong R, Miller K, et al. Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development. Cancer Discov. 2016;6:188-201 pubmed publisher
Bourcier C, Michel Flutot P, Emam L, Adam L, Gasser A, Vinit S, et al. ß1-adrenergic blockers preserve neuromuscular function by inhibiting the production of extracellular traps during systemic inflammation in mice. Front Immunol. 2023;14:1228374 pubmed publisher
Fantone K, Goldberg J, Stecenko A, Rada B. Sputum from People with Cystic Fibrosis Reduces the Killing of Methicillin-Resistant Staphylococcus aureus by Neutrophils and Diminishes Phagosomal Production of Reactive Oxygen Species. Pathogens. 2023;12: pubmed publisher
Liu D, Pahar B, Perry D, Xu H, Cooper T, Huzella L, et al. Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease. Am J Pathol. 2023;193:2031-2046 pubmed publisher
Lee S, Baek S, Lee Y, Kim T, Yim J, Son J, et al. Ginsenoside Rg3-enriched Korean Red Ginseng extract attenuates Non-Alcoholic Fatty Liver Disease by way of suppressed VCAM-1 expression in liver sinusoidal endothelium. J Ginseng Res. 2023;47:429-439 pubmed publisher
Silva B, Gomes G, Veras F, Cambier S, Silva G, Quadros A, et al. C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps. J Clin Invest. 2023;133: pubmed publisher
Krinsky N, Sizikov S, Nissim S, Dror A, Sas A, Prinz H, et al. NETosis induction reflects COVID-19 severity and long COVID: insights from a 2-center patient cohort study in Israel. J Thromb Haemost. 2023;21:2569-2584 pubmed publisher
Lienard J, Munke K, Wulff L, Da Silva C, Vandamme J, Laschanzky K, et al. Intragranuloma Accumulation and Inflammatory Differentiation of Neutrophils Underlie Mycobacterial ESX-1-Dependent Immunopathology. MBio. 2023;14:e0276422 pubmed publisher
Gupta T, Sarr D, Fantone K, Ashtiwi N, Sakamoto K, Quinn F, et al. Dual oxidase 1 is dispensable during Mycobacterium tuberculosis infection in mice. Front Immunol. 2023;14:1044703 pubmed publisher
Doudin A, Riebeling T, Staab J, Menon P, L xfc hder F, Wirths O, et al. Lack of STAT1 co-operative DNA binding protects against adverse cardiac remodelling in acute myocardial infarction. Front Cardiovasc Med. 2023;10:975012 pubmed publisher
Veras F, Gomes G, Silva B, Caetit xe9 D, Almeida C, Silva C, et al. Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model. Respir Res. 2023;24:66 pubmed publisher
Staab J, Vonh xf6 ren L, Schw xf6 rer H, Meyer T. Association between self-rated depressive symptoms and mucosal expression of NF-κ B in patients with upper gastrointestinal symptoms. Biopsychosoc Med. 2023;17:6 pubmed publisher
Jeong H, Hong E, Ahn J, Cho J, Jeong J, Kim C, et al. ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions. Exp Mol Med. 2023;55:401-412 pubmed publisher
Jacenik D, Karagiannidis I, Beswick E. Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils. Br J Cancer. 2023;128:387-397 pubmed publisher
Carai P, Gonz xe1 lez L, Van Bruggen S, Spalart V, De Giorgio D, Geuens N, et al. Neutrophil inhibition improves acute inflammation in a murine model of viral myocarditis. Cardiovasc Res. 2023;118:3331-3345 pubmed publisher
Alyamani M, Kadivar M, Erjef xe4 lt J, Johansson Lindbom B, Duan R, Nilsson x, et al. Alkaline sphingomyelinase (NPP7) impacts the homeostasis of intestinal T lymphocyte populations. Front Immunol. 2022;13:1050625 pubmed publisher
Veras F, Publio G, Melo B, Prado D, Norbiato T, Cecílio N, et al. Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation. Cell Rep. 2022;41:111897 pubmed publisher
Morita Y, Itokazu T, Nakanishi T, Hiraga S, Yamashita T. A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations. J Neuroinflammation. 2022;19:263 pubmed publisher
Matsuo R, Kishibe M, Horiuchi K, Kano K, Tatsukawa T, Hayasaka T, et al. Ninjurin1 Deletion in NG2-Positive Pericytes Prevents Microvessel Maturation and Delays Wound Healing. JID Innov. 2022;2:100141 pubmed publisher
Martens C, Van Mol P, Wauters J, Wauters E, Gangnus T, Noppen B, et al. Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19. EBioMedicine. 2022;83:104195 pubmed publisher
Wang Z, Popowski K, Zhu D, de Juan Abad B, Wang X, Liu M, et al. Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine. Nat Biomed Eng. 2022;6:791-805 pubmed publisher
Muhammad W, Zhu J, Zhai Z, Xie J, Zhou J, Feng X, et al. ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment. Acta Biomater. 2022;148:258-270 pubmed publisher
Lee S, Lee Y, Baek S, Kang K, Kim T, Yim J, et al. Mega-Dose Vitamin C Ameliorates Nonalcoholic Fatty Liver Disease in a Mouse Fast-Food Diet Model. Nutrients. 2022;14: pubmed publisher
Hsu C, Chávez C, Zhang C, Sowden M, Yan C, Berk B. The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis. Cell Death Differ. 2022;: pubmed publisher
Wang X, Xu L, Wang T, Xu J, Fan F, Zhang Y, et al. Pulsatilla decoction alleviates colitis by enhancing autophagy and regulating PI3K‑Akt‑mTORC1 signaling pathway. Mol Med Rep. 2022;25: pubmed publisher
Zhan Y, Ling Y, Deng Q, Qiu Y, Shen J, Lai H, et al. HMGB1-Mediated Neutrophil Extracellular Trap Formation Exacerbates Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury. J Immunol. 2022;208:968-978 pubmed publisher
Guo Z, Chen J, Zeng Y, Wang Z, Yao M, Tomlinson S, et al. Complement Inhibition Alleviates Cholestatic Liver Injury Through Mediating Macrophage Infiltration and Function in Mice. Front Immunol. 2021;12:785287 pubmed publisher
Petrigliano F, Liu N, Lee S, Tassey J, Sarkar A, Lin Y, et al. Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes. NPJ Regen Med. 2021;6:77 pubmed publisher
Wang J, Jalali Motlagh N, Wang C, Wojtkiewicz G, Schmidt S, Chau C, et al. d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Raghavan J, Ganesh R, Sonpatki P, Naik D, John A, Arunachalam P, et al. Immuno-phenotyping of IDH-mutant grade 3 astrocytoma and IDH-wildtype glioblastoma reveals specific differences in cells of myeloid origin. Oncoimmunology. 2021;10:1957215 pubmed publisher
Dhawan U, Bhattacharya P, Narayanan S, Manickam V, Aggarwal A, Subramanian M. Hypercholesterolemia Impairs Clearance of Neutrophil Extracellular Traps and Promotes Inflammation and Atherosclerotic Plaque Progression. Arterioscler Thromb Vasc Biol. 2021;41:2598-2615 pubmed publisher
Vanderbeke L, Van Mol P, van Herck Y, De Smet F, Humblet Baron S, Martinod K, et al. Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity. Nat Commun. 2021;12:4117 pubmed publisher
Hsu C, Fazal F, Rahman A, Berk B, Yan C. Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation. J Immunol. 2021;206:3010-3020 pubmed publisher
Fang Z, Kim H, Huang M, Chowdhury K, Li M, Liangpunsakul S, et al. Sestrin Proteins Protect Against Lipotoxicity-Induced Oxidative Stress in the Liver via Suppression of C-Jun N-Terminal Kinases. Cell Mol Gastroenterol Hepatol. 2021;12:921-942 pubmed publisher
Chen T, Tan X, Xia F, Hua Y, Keep R, Xi G. Hydrocephalus Induced by Intraventricular Peroxiredoxin-2: The Role of Macrophages in the Choroid Plexus. Biomolecules. 2021;11: pubmed publisher
Zhu D, Li Z, Huang K, Caranasos T, Rossi J, Cheng K. Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair. Nat Commun. 2021;12:1412 pubmed publisher
Payne G, Sharma N, Lal C, Song C, Guo L, Margaroli C, et al. Prolyl endopeptidase contributes to early neutrophilic inflammation in acute myocardial transplant rejection. JCI Insight. 2021;6: pubmed publisher
Xie M, Li J, Zhang S, Zhu D, Mei X, Wang Z, et al. A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse. Bioact Mater. 2021;6:1777-1788 pubmed publisher
Jin Z, Sun J, Song Z, Chen K, Nicolas Y, Kc R, et al. Neutrophil extracellular traps promote scar formation in post-epidural fibrosis. NPJ Regen Med. 2020;5:19 pubmed publisher
Dupuis J, Sirois M, Rhéaume E, Nguyen Q, Clavet Lanthier M, Brand G, et al. Colchicine reduces lung injury in experimental acute respiratory distress syndrome. PLoS ONE. 2020;15:e0242318 pubmed publisher
Macedo I, Lima M, Souza J, Rochael N, Caldas P, Barbosa H, et al. Extracellular Traps Released by Neutrophils from Cats are Detrimental to Toxoplasma gondii Infectivity. Microorganisms. 2020;8: pubmed publisher
Gerber A, Goldklang M, Stearns K, Ma X, Xiao R, Zelonina T, et al. Attenuation of pulmonary injury by an inhaled MMP inhibitor in the endotoxin lung injury model. Am J Physiol Lung Cell Mol Physiol. 2020;319:L1036-L1047 pubmed publisher
Veras F, Pontelli M, Silva C, Toller Kawahisa J, de Lima M, Nascimento D, et al. SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology. J Exp Med. 2020;217: pubmed publisher
Vaibhav K, Braun M, Alverson K, Khodadadi H, Kutiyanawalla A, Ward A, et al. Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury. Sci Adv. 2020;6:eaax8847 pubmed publisher
Zhong X, Huang M, Kim H, Zhang Y, Chowdhury K, Cai W, et al. SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells. Cell Mol Gastroenterol Hepatol. 2020;10:341-364 pubmed publisher
Tan X, Chen J, Keep R, Xi G, Hua Y. Prx2 (Peroxiredoxin 2) as a Cause of Hydrocephalus After Intraventricular Hemorrhage. Stroke. 2020;51:1578-1586 pubmed publisher
Greenberg A, Huber B, Liu D, Logue J, Hischak A, Hart R, et al. Quantification of Viral and Host Biomarkers in the Liver of Rhesus Macaques: A Longitudinal Study of Zaire Ebolavirus Strain Kikwit (EBOV/Kik). Am J Pathol. 2020;190:1449-1460 pubmed publisher
Henn D, Chen K, Maan Z, Greco A, Moortgat Illouz S, Bonham C, et al. Cryopreserved human skin allografts promote angiogenesis and dermal regeneration in a murine model. Int Wound J. 2020;17:925-936 pubmed publisher
Mareninova O, Jia W, Gretler S, Holthaus C, Thomas D, Pimienta M, et al. Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice. Autophagy. 2020;16:2084-2097 pubmed publisher
Liu F, Fu J, Bergstrom K, Shan X, McDaniel J, McGee S, et al. Core 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer. J Exp Med. 2020;217: pubmed publisher
Willis K, Siefker D, Aziz M, White C, Mussarat N, Gomes C, et al. Perinatal maternal antibiotic exposure augments lung injury in offspring in experimental bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2020;318:L407-L418 pubmed publisher
Bian L, Zhang J, Wang M, Keep R, Xi G, Hua Y. Intracerebral Hemorrhage-Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2. Transl Stroke Res. 2019;: pubmed publisher
Liu G, Mateer S, Hsu A, Goggins B, Tay H, Mathe A, et al. Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome. Mucosal Immunol. 2019;: pubmed publisher
Gao F, Liu X, Shen Z, Jia X, He H, Gao J, et al. Andrographolide Sulfonate Attenuates Acute Lung Injury by Reducing Expression of Myeloperoxidase and Neutrophil-Derived Proteases in Mice. Front Physiol. 2018;9:939 pubmed publisher
Zhao M, Xiong X, Ren K, Xu B, Cheng M, Sahu C, et al. Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation. EMBO Mol Med. 2018;10: pubmed publisher
Voss J, Stermer A, Ghaffari R, Tiwary R, Richburg J. MEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis. Reproduction. 2018;156:35-46 pubmed publisher
Biron B, Chung C, Chen Y, Wilson Z, Fallon E, Reichner J, et al. PAD4 Deficiency Leads to Decreased Organ Dysfunction and Improved Survival in a Dual Insult Model of Hemorrhagic Shock and Sepsis. J Immunol. 2018;200:1817-1828 pubmed publisher
Li D, Fu H, Tong J, Li Y, Qu L, Wang P, et al. Cholinergic anti-inflammatory pathway inhibits neointimal hyperplasia by suppressing inflammation and oxidative stress. Redox Biol. 2018;15:22-33 pubmed publisher
Guo Y, Zhang M, Wang F, Pei G, Sun F, Zhang Y, et al. Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2-Dependent Phosphatidylinositol 3-Kinase-AKT-Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1?/Vascular. Am J Pathol. 2017;187:1736-1749 pubmed publisher
Kongphat W, Pudgerd A, Sridurongrit S. Hepatocyte-specific expression of constitutively active Alk5 exacerbates thioacetamide-induced liver injury in mice. Heliyon. 2017;3:e00305 pubmed publisher
Qian B, Ji M, Qiu Y, Pan T, Wang B, Mao S, et al. Is There any Correlation Between Pathological Profile of Facet Joints and Clinical Feature in Patients With Thoracolumbar Kyphosis Secondary to Ankylosing Spondylitis?: An Immunohistochemical Investigation. Spine (Phila Pa 1976). 2016;41:E512-8 pubmed publisher
Dong Z, Chen J, Ruan Y, Zhou T, Chen Y, Chen Y, et al. CFTR-regulated MAPK/NF-κB signaling in pulmonary inflammation in thermal inhalation injury. Sci Rep. 2015;5:15946 pubmed publisher
Lin A, Beasley F, Olson J, Keller N, Shalwitz R, Hannan T, et al. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015;11:e1004818 pubmed publisher
Leclerc J, Lampert A, Diller M, DORE S. Genetic deletion of the prostaglandin E2 E prostanoid receptor subtype 3 improves anatomical and functional outcomes after intracerebral hemorrhage. Eur J Neurosci. 2015;41:1381-91 pubmed publisher
Kessinger C, Kim J, Henke P, Thompson B, McCarthy J, Hara T, et al. Statins improve the resolution of established murine venous thrombosis: reductions in thrombus burden and vein wall scarring. PLoS ONE. 2015;10:e0116621 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Myeloperoxidase Polyclonal Antibody
Catalog # :
PA5-16672
Quantity :
500 uL
Price :
US 460.00
Clonality :
Polyclonal
Purity :
purified
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
ELISA: 1:1,000, Immunohistochemistry (Paraffin): 1:100-1:200
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
4 C
Description :
Myeloperoxidase (MPO) is a heme protein that is synthesized during myeloid differentiation and is a major component of neutrophil azurophilic granules. It is produced as a single chain precursor and subsequently cleaved into a light and heavy chain. The mature MPO is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme is responsible for producing hypohalous acids that are central to the microbicidal activity of neutrophils. Diseases that are associated with MPO include Myeloperoxidase Deficiency and Alzheimer's Disease, Familial, 1.
Immunogen :
Purified human granulocytic MPO
Format :
Liquid
Applications w/Dilutions :
ELISA: 1:1,000, Immunohistochemistry (Paraffin): 1:100-1:200
Aliases :
84 kDa myeloperoxidase; 89 kDa myeloperoxidase; mKIAA4033; MPO; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA