alpha-1 Antitrypsin Polyclonal Antibody | Invitrogen PA5-16661 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

alpha-1 Antitrypsin Polyclonal Antibody

catalog :

PA5-16661

quantity :

500 µL

price :

US 410

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 2

Reference
Tiensuu H, Haapalainen A, Tissarinen P, Pasanen A, M xe4 xe4 tt xe4 T, Huusko J, et al. Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth. BMC Med. 2022;20:141 pubmed publisher
Onur T, Laitman A, Zhao H, Keyho R, Kim H, Wang J, et al. Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis. elife. 2021;10: pubmed publisher

product information

Product Type :

Antibody

Product Name :

alpha-1 Antitrypsin Polyclonal Antibody

Catalog # :

PA5-16661

Quantity :

500 µL

Price :

US 410

Clonality :

Polyclonal

Purity :

purified

Host :

Rabbit

Reactivity :

Equine, Human, Mink, Non-human primate

Applications :

Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 1:250

Species :

Equine, Human, Mink, Non-human primate

Isotype :

IgG

Storage :

4° C

Description :

Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

Immunogen :

Purified human serum alpha-1-AT

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 1:250

Aliases :

a-1 AT; A1A; a1-antitrypsin; A1AT; AAT; Aat2; Aat-2; alpha 1 antitrypsin; alpha-1 antitrypsin; alpha-1 protease inhibitor; Alpha-1 protease inhibitor 1; alpha-1-antiproteinase; Alpha-1-antitrypsin; alpha-1-antitrypsin (protease inhibitor); alpha-1-antitrypsin 1-1; alpha-1-antitrypsin 2; alpha-1-antitrypsin null; alpha1AT; alpha-1-protease inhibitor; alpha-1-proteinase inhibitor; Digestive Zymogen; Dom1; MGC23330; MGC9222; PI; PI1; PRO0684; PRO2209; PRO2275; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; Protease Serine 1; serine (or cysteine) peptidase inhibitor, clade A, member 1A; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1a; Serine Protease 1; serine protease inhibitor 1-1; Serine protease inhibitor A1a; serine protease inhibitor alpha 1; Serpin A1; Serpin A1a; serpin family A member 1; serpin peptidase inhibitor clade A member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Serpina1; Serpina1a; Short peptide from AAT; SPAAT; Spi1; Spi1-1; Spi1-3; TRP1; TRY1