Ki-67 Polyclonal Antibody | Invitrogen PA5-16446 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ki-67 Polyclonal Antibody

catalog :

PA5-16446

quantity :

500 µL

price :

US 496.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 16

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:200; fig 6	Huang G, Yang X, Chen K, Xing J, Guo L, Zhu L, et al. Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/?-Catenin Pathway by Its GAP Domain. Front Cell Neurosci. 2016;10:85 pubmed publisher
immunohistochemistry - frozen section; human; fig 3	Haemmerle M, Bottsford Miller J, Pradeep S, Taylor M, Choi H, Hansen J, et al. FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal. J Clin Invest. 2016;126:1885-96 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:300; fig 1c	Park J, Han C, Zhao L, Willingham M, Cheng S. Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model. Endocr Relat Cancer. 2016;23:53-63 pubmed publisher
	Veiga A, Irioda A, Mogharbel B, Bonatto S, Souza L. Quercetin-Rich Extracts from Onions (Allium cepa) Play Potent Cytotoxicity on Adrenocortical Carcinoma Cell Lines, and Quercetin Induces Important Anticancer Properties. Pharmaceuticals (Basel). 2022;15: pubmed publisher
	Zhang X, Wang J, Wang Y, Liu G, Li H, Yu J, et al. MELK Inhibition Effectively Suppresses Growth of Glioblastoma and Cancer Stem-Like Cells by Blocking AKT and FOXM1 Pathways. Front Oncol. 2020;10:608082 pubmed publisher
	Wang Y, Huang Y, Xu X, Chen B, Lin Z, Ma Y, et al. Curative effect of methotrexate combined with teniposide in the treatment of primary central nervous system lymphoma. Oncol Lett. 2020;19:2097-2106 pubmed publisher
	Bertacchi M, Gruart A, Kaimakis P, Allet C, Serra L, Giacobini P, et al. Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome. EMBO Mol Med. 2019;11:e10291 pubmed publisher
	Schade G, Wang Y, D Andrea S, Hwang J, Liles W, Khokhlova T. Boiling Histotripsy Ablation of Renal Cell Carcinoma in the Eker Rat Promotes a Systemic Inflammatory Response. Ultrasound Med Biol. 2019;45:137-147 pubmed publisher
	Žunić Išasegi I, Rados M, Krsnik Z, Rados M, Benjak V, Kostovic I. Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall. Brain Struct Funct. 2018;223:3919-3943 pubmed publisher
	Xia D, Ji W, Xu C, Lin X, Wang X, Xia Y, et al. Knockout of MARCH2 inhibits the growth of HCT116 colon cancer cells by inducing endoplasmic reticulum stress. Cell Death Dis. 2017;8:e2957 pubmed publisher
	Bai Y, Shao Y, Li H, Xue W, Quan F, Wu S. Ki-67 is overexpressed in human laryngeal carcinoma and contributes to the proliferation of HEp2 cells. Oncol Lett. 2016;12:2641-2647 pubmed
	Fu Y, Cruz Monserrate Z, Helen Lin H, Chung Y, Ji B, Lin S, et al. Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype. Sci Rep. 2015;5:13347 pubmed publisher
	Rowson Hodel A, Manjarin R, Trott J, Cardiff R, Borowsky A, Hovey R. Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. BMC Cancer. 2015;15:562 pubmed publisher
	Park J, Zhao L, Willingham M, Cheng S. Oncogenic mutations of thyroid hormone receptor Î². Oncotarget. 2015;6:8115-31 pubmed
	Ahmed H, Shousha W, Shalby A, El Mezayen H, Ismaiel N, Mahmoud N. Curcumin: a unique antioxidant offers a multimechanistic approach for management of hepatocellular carcinoma in rat model. Tumour Biol. 2015;36:1667-78 pubmed publisher
	Fan C, Jiang G, Zhang X, Miao Y, Lin X, Luan L, et al. Zbed3 contributes to malignant phenotype of lung cancer via regulating Î²-catenin and P120-catenin 1. Mol Carcinog. 2015;54 Suppl 1:E138-47 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Ki-67 Polyclonal Antibody

Catalog # :

PA5-16446

Quantity :

500 µL

Price :

US 496.00

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 10-20 µg/mL

Species :

Human, Rat

Isotype :

IgG

Storage :

4° C

Description :

Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.

Immunogen :

A synthetic peptide from the human Ki67 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 10-20 µg/mL

Aliases :

antigen identified by monoclonal antibody Ki 67; antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki-67 homolog; Antigen KI-67; Antigen KI-67 homolog; antigen KI-67; proliferation marker protein Ki-67; antigen KI-67-like; cb31; D630048A14Rik; I79_022666; Ki67; Ki-67; KIA; LOW QUALITY PROTEIN: proliferation marker protein Ki-67; marker of proliferation Ki-67; MIB-; MIB-1; Mki67; PPP1R105; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; RP11-380J17.2; sb:cb31; si:ch211-250b22.7; unnamed protein product; wu:fa11g09; wu:fb57a07; wu:fi14e05