This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Caspase 3 Polyclonal Antibody
catalog :
PA5-16335
quantity :
500µL
price :
US 349.00
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
Chinese hamster, human, mouse, rat, dog, cow, pig, sheep, rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 35
Published Application/Species/DilutionReference
  • immunohistochemistry - paraffin section; rat; 1 ug/ml
Galal A, El-Bakly W, Al Haleem E, El-Demerdash E. Selective A3 adenosine receptor agonist protects against doxorubicin-induced cardiotoxicity. Cancer Chemother Pharmacol. 2016;77:309-22 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; fig 4
Feng N, Hao G, Yang F, Qu F, Zheng H, Liang S, et al. Transplantation of mesenchymal stem cells promotes the functional recovery of the central nervous system following cerebral ischemia by inhibiting myelin-associated inhibitor expression and neural apoptosis. Exp Ther Med. 2016;11:1595-1600 pubmed
  • immunohistochemistry - paraffin section; rat; ready-to-use
Ozacmak V, Sayan-Ozacmak H, Barut F. Chronic treatment with resveratrol, a natural polyphenol found in grapes, alleviates oxidative stress and apoptotic cell death in ovariectomized female rats subjected to chronic cerebral hypoperfusion. Nutr Neurosci. 2016;19:176-86 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 4
Kolisnyk B, Al-Onaizi M, Soreq L, Barbash S, Bekenstein U, Haberman N, et al. Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology. Cereb Cortex. 2016;: pubmed
  • immunohistochemistry - paraffin section; human; 1:100
De Luca A, Rotili D, Carpanese D, Lenoci A, Calderan L, Scimeca M, et al. A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts. Oncotarget. 2015;6:4126-43 pubmed
  • immunohistochemistry - paraffin section; mouse; ready-to-use
Ashour D, Othman A, Radi D. Insights into regulatory molecules of intestinal epithelial cell turnover during experimental infection by Heterophyes heterophyes. Exp Parasitol. 2014;143:48-54 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100
Pun P, Kan E, Salim A, Li Z, Ng K, Moochhala S, et al. Low level primary blast injury in rodent brain. Front Neurol. 2011;2:19 pubmed
  • immunohistochemistry - paraffin section; rat; 1:100; fig 13
Zou Y, Kan E, Lu J, Ng K, Tan M, Yao L, et al. Primary blast injury-induced lesions in the retina of adult rats. J Neuroinflammation. 2013;10:79 pubmed publisher
  • immunohistochemistry; rat; 1:20; fig 4
Damron T, Mathur S, Horton J, Strauss J, Margulies B, Grant W, et al. Temporal changes in PTHrP, Bcl-2, Bax, caspase, TGF-beta, and FGF-2 expression following growth plate irradiation with or without radioprotectant. J Histochem Cytochem. 2004;52:157-67 pubmed
  • immunohistochemistry - paraffin section; rat; ready to use
Ozkan G, Ulusoy S, Orem A, Alkanat M, Mungan S, Yulug E, et al. How does colistin-induced nephropathy develop and can it be treated?. Antimicrob Agents Chemother. 2013;57:3463-9 pubmed publisher
Kanter M, Unsal C, Aktas C, Erboga M. Neuroprotective effect of quercetin against oxidative damage and neuronal apoptosis caused by cadmium in hippocampus. Toxicol Ind Health. 2016;32:541-50 pubmed publisher
Saad D, Baiomy A, Mansour A. Antiseptic effect of sea cucumber (Holothuria atra) against multi-organ failure induced by sepsis: Molecular and histopathological study. Exp Ther Med. 2016;12:222-230 pubmed
Unsal C, Kanter M, Aktas C, Erboga M. Role of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats. Toxicol Ind Health. 2015;31:1106-15 pubmed publisher
Al-Salam S, Hashmi S. Galectin-1 in early acute myocardial infarction. PLoS ONE. 2014;9:e86994 pubmed publisher
Kasem R, Hegazy R, Arafa M, Abdelmohsen M. Chemopreventive effect of Mentha piperita on dimethylbenz[a]anthracene and formaldehyde-induced tongue carcinogenesis in mice (histological and immunohistochemical study). J Oral Pathol Med. 2014;43:484-91 pubmed publisher
Ozaçmak H, Ozacmak V, Barut F, Arasli M, Ucan B. Pretreatment with mineralocorticoid receptor blocker reduces intestinal injury induced by ischemia and reperfusion: involvement of inhibition of inflammatory response, oxidative stress, nuclear factor κB, and inducible nitric oxide synthase. J Surg Res. 2014;191:350-61 pubmed publisher
Mor F, Kilic M, Ozmen O, Yilmaz M, Eker I, Uran K. The effects of orchidectomy on toxicological responses to dietary ochratoxin A in Wistar rats. Exp Toxicol Pathol. 2014;66:267-75 pubmed publisher
Kömür M, Okuyaz C, Celik Y, Resitoglu B, Polat A, Balci S, et al. Neuroprotective effect of levetiracetam on hypoxic ischemic brain injury in neonatal rats. Childs Nerv Syst. 2014;30:1001-9 pubmed publisher
Ulusoy S, Ozkan G, Mungan S, Orem A, Yulug E, Alkanat M, et al. GSPE is superior to NAC in the prevention of contrast-induced nephropathy: might this superiority be related to caspase 1 and calpain 1?. Life Sci. 2014;103:101-10 pubmed publisher
Wang X, Luo K, Bella A, Bu S, Wen J, Zhang S, et al. Caspase-3 expression in metastatic lymph nodes of esophageal squamous cell carcinoma is prognostic of survival. World J Gastroenterol. 2014;20:4414-20 pubmed publisher
Ozmen O. Cardiotoxicity and apoptotic activity in subacute endosulfan toxicity and the protective effect of vitamin C in rabbits: a pathological study. J Environ Pathol Toxicol Oncol. 2013;32:53-8 pubmed
Kaya-Dagistanli F, Tanriverdi G, Altınok A, Ozyazgan S, Ozturk M. The effects of alpha lipoic acid on liver cells damages and apoptosis induced by polyunsaturated fatty acids. Food Chem Toxicol. 2013;53:84-93 pubmed publisher
Kilic S, Yuksel B, Lortlar N, Sertyel S, Aksu T, Batioglu S. Environmental tobacco smoke exposure during intrauterine period promotes granulosa cell apoptosis: a prospective, randomized study. J Matern Fetal Neonatal Med. 2012;25:1904-8 pubmed publisher
Morsy M, El-Moselhy M. Mechanisms of the protective effects of curcumin against indomethacin-induced gastric ulcer in rats. Pharmacology. 2013;91:267-74 pubmed publisher
Ulusoy S, Ozkan G, Alkanat M, Mungan S, Yulug E, Orem A. Perspective on rhabdomyolysis-induced acute kidney injury and new treatment options. Am J Nephrol. 2013;38:368-78 pubmed publisher
Kanter M. Protective effects of quercetine on the neuronal injury in frontal cortex after chronic toluene exposure. Toxicol Ind Health. 2013;29:643-51 pubmed publisher
Tasdemir N, Kilic S, Lortlar N, Yuksel B, Goker U, Ozaksit G. Time dependent influence of etonogestrel on the caspase-3 immunoreactivity and apoptotic indexes of rat uterus and ovaries. Gynecol Endocrinol. 2012;28:463-7 pubmed publisher
Ribeiro P, Rodrigues P, Valentim A, Antunes L. A single intraperitoneal injection of ketamine does not affect spatial working, reference memory or neurodegeneration in adult mice: An animal study. Eur J Anaesthesiol. 2013;30:618-26 pubmed publisher
Oyar E, Kiris I, Gulmen S, Ceyhan B, Cüre M, Delibas N, et al. The protective effect of adrenomedullin on renal injury, in a model of abdominal aorta cross-clamping. Thorac Cardiovasc Surg. 2012;60:5-10 pubmed publisher
Jin X, Cao M, Zhou X, Yin H, Chen Z, Xu N, et al. Effect of different durations of overdistention on rat bladder function and morphology. Braz J Med Biol Res. 2012;45:921-8 pubmed
Kerman M, Kanter M, Coskun K, Erboga M, Gurel A. Neuroprotective effects of caffeic acid phenethyl ester on experimental traumatic brain injury in rats. J Mol Histol. 2012;43:49-57 pubmed publisher
Hua S, Zhang X, Zhang S, Xu J, Feng Z. Effects of different ventilation strategies on lung injury in newborn rabbits. Pediatr Pulmonol. 2012;47:1103-12 pubmed publisher
Tayman C, Tonbul A, Köşüş A, Hirfanoglu I, Uysal S, Haltas H, et al. N-acetylcysteine may prevent severe intestinal damage in necrotizing enterocolitis. J Pediatr Surg. 2012;47:540-50 pubmed publisher
Sotres-Vega A, Santibáñez-Salgado J, Villalba-Caloca J, Gaxiola-Gaxiola M, Ramos-Abraham C, Rosales-Torres A, et al. Canine tracheal cartilage cryopreservation: freezing injury is not related to caspase-3 expression. Biopreserv Biobank. 2013;11:45-50 pubmed publisher
Kutlu O, Cansu A, Karaguzel E, Gürgen S, Koç O, Gür M, et al. Effect of valproic acid treatment on penile structure in prepubertal rats. Epilepsy Res. 2012;99:306-11 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Caspase 3 Polyclonal Antibody
Catalog # :
PA5-16335
Quantity :
500µL
Price :
US 349.00
Clonality :
Polyclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Ovine, Porcine, Rabbit, Rat
Applications :
Immunocytochemistry: 2µg/ml, Immunofluorescence: 2µg/ml, Immunohistochemistry (Paraffin): 5-10 ug/mL, Immunoprecipitation: 10 ug/mg protein lysate, Western Blot: 2.5-5 ug/ml
Species :
Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Ovine, Porcine, Rabbit, Rat
Isotype :
IgG
Storage :
4° C
Description :
Caspase 3 is ubiquitously expressed and like other caspases is synthesized as an inactive (32kDa) proenzyme. Upon activation, Caspase 3 is cleaved at Asp28-Ser29 and Asp175-Ser176 thereby generating two subunits of 17kDa and 12kDa, respectively. Recent studies have implicated that Caspase 3 is associated with the induction of apoptosis. Activation of Caspase 3 occurs in response to variety of apoptotic inducers including Fas mediated apoptosis.
Immunogen :
Recombinant full length human caspase 3 protein
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 2µg/ml, Immunofluorescence: 2µg/ml, Immunohistochemistry (Paraffin): 5-10 ug/mL, Immunoprecipitation: 10 ug/mg protein lysate, Western Blot: 2.5-5 ug/ml
Aliases :
CASP-3, CPP-32,PARP cleavage protease, SREBP cleavage activity 1, Yama, apopain, caspase 3, apoptosis-related cysteine protease, caspase-3, cysteine protease CPP32, procaspase3, protein Yama
PubMed References :
14729867, 21541261, 22124729, 22222684, 22252859, 22281060, 22424351, 22451169, 22468922, 22578029, 22735176, 23200892, 23629704, 23645211, 23689497, 23736087, 23758152, 23819902, 24158126, 24193051, 24450492, 24498007, 24526342, 24727104, 24764681, 24813088, 24845254, 24852217, 24862878, 25595904, 26005194, 26676227, 27168778, 27312991
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
www.thermofisher.com
800-678-5599
headquarters: USA