product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
GFAP Polyclonal Antibody
catalog :
PA5-16291
quantity :
500 uL
price :
US 562.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
Chinese hamsters, guinea pig, human, mouse, rat, chicken, bovine, domestic sheep
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 33
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; fig 2a
Niu M, Zhao F, Bondelid K, Siedlak S, Torres S, Fujioka H, et al. VPS35 D620N knockin mice recapitulate cardinal features of Parkinson's disease. Aging Cell. 2021;20:e13347 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 7b
Zhao F, Austria Q, Wang W, Zhu X. Mfn2 Overexpression Attenuates MPTP Neurotoxicity In Vivo. Int J Mol Sci. 2021;22: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 3f
Gao J, Wu Y, He D, Zhu X, Li H, Liu H, et al. Anti-aging effects of Ribes meyeri anthocyanins on neural stem cells and aging mice. Aging (Albany NY). 2020;12:17738-17753 pubmed publisher
  • immunohistochemistry - paraffin section; rat; ready-to-use
Ozacmak V, Sayan Ozacmak H, Barut F. Chronic treatment with resveratrol, a natural polyphenol found in grapes, alleviates oxidative stress and apoptotic cell death in ovariectomized female rats subjected to chronic cerebral hypoperfusion. Nutr Neurosci. 2016;19:176-86 pubmed publisher
Yang S, Huang L, Liang H, Guo J, Liu L, Chen S, et al. Loss of flrt2 gene leads to microphthalmia in zebrafish. Biol Open. 2023;12: pubmed publisher
Mokhtar D, Sayed R, Zaccone G, Alesci A, Hussein M. The potential role of the pseudobranch of molly fish (Poecilia sphenops) in immunity and cell regeneration. Sci Rep. 2023;13:8665 pubmed publisher
Cervetto C, Pistollato F, Amato S, Mendoza de Gyves E, Bal Price A, Maura G, et al. Assessment of neurotransmitter release in human iPSC-derived neuronal/glial cells: a missing in vitro assay for regulatory developmental neurotoxicity testing. Reprod Toxicol. 2023;117:108358 pubmed publisher
Cramer S, Haley S, Popa L, Carter R, Scott E, Flaherty E, et al. Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse. Neurobiol Dis. 2023;176:105943 pubmed publisher
Zhou L, Guo T, Meng L, Zhang X, Tian Y, Dai L, et al. N-homocysteinylation of α-synuclein promotes its aggregation and neurotoxicity. Aging Cell. 2023;22:e13745 pubmed publisher
Henao Restrepo J, L xf3 pez Murillo C, Valderrama Carmona P, Orozco Santa N, Gomez J, Guti xe9 rrez Vargas J, et al. Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection. Brain Pathol. 2023;33:e13119 pubmed publisher
Amruta N, Ismael S, Leist S, Gressett T, Srivastava A, Dinnon K, et al. Mouse Adapted SARS-CoV-2 (MA10) Viral Infection Induces Neuroinflammation in Standard Laboratory Mice. Viruses. 2022;15: pubmed publisher
Jim xe9 nez S, Moreno N. Development of subdomains in the medial pallium of Xenopus laevis and Trachemys scripta: Insights into the anamniote-amniote transition. Front Neuroanat. 2022;16:1039081 pubmed publisher
Kunder N, de la Pe xf1 a J, Lou T, Chase R, Suresh P, Lawson J, et al. The RNA-Binding Protein HuR Is Integral to the Function of Nociceptors in Mice and Humans. J Neurosci. 2022;42:9129-9141 pubmed publisher
Mokhtar D, Sayed R, Zaccone G, Albano M, Hussein M. Ependymal and Neural Stem Cells of Adult Molly Fish (Poecilia sphenops, Valenciennes, 1846) Brain: Histomorphometry, Immunohistochemical, and Ultrastructural Studies. Cells. 2022;11: pubmed publisher
Ballarino R, Bouwman B, Agostini F, Harbers L, Diekmann C, Wernersson E, et al. An atlas of endogenous DNA double-strand breaks arising during human neural cell fate determination. Sci Data. 2022;9:400 pubmed publisher
Eriksson D, Schneider A, Thirumalai A, Alyahyay M, de la Crompe B, Sharma K, et al. Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation. Nat Commun. 2022;13:985 pubmed publisher
Chacko A, Delbaz A, Walkden H, Basu S, Armitage C, Eindorf T, et al. Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer's disease risk. Sci Rep. 2022;12:2759 pubmed publisher
Zhao X, Hasan S, Liou B, Lin Y, Sun Y, Liu C. Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice. Int J Mol Sci. 2022;23: pubmed publisher
Daenzer J, Rasmussen S, Patel S, McKenna J, Fridovich Keil J. Neonatal GALT gene replacement offers metabolic and phenotypic correction through early adulthood in a rat model of classic galactosemia. J Inherit Metab Dis. 2022;45:203-214 pubmed publisher
Zhao F, Xu Y, Gao S, Qin L, Austria Q, Siedlak S, et al. METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events. Mol Neurodegener. 2021;16:70 pubmed publisher
Cone A, Yuan X, Sun L, Duke L, Vreones M, Carrier A, et al. Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model. Theranostics. 2021;11:8129-8142 pubmed publisher
González Molina L, Villar Vesga J, Henao Restrepo J, Villegas A, Lopera F, Cardona Gómez G, et al. Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer's Disease Patient Astrocytes Impair Neuroglial and Vascular Components. Front Aging Neurosci. 2021;13:593927 pubmed publisher
Li Y, Ritzel R, Khan N, Cao T, He J, Lei Z, et al. Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice. Theranostics. 2020;10:11376-11403 pubmed publisher
Sánchez B, Bort A, Vara Ciruelos D, Díaz Laviada I. Androgen Deprivation Induces Reprogramming of Prostate Cancer Cells to Stem-Like Cells. Cells. 2020;9: pubmed publisher
Hennes M, Lombaert N, Wahis J, Van den Haute C, Holt M, Arckens L. Astrocytes shape the plastic response of adult cortical neurons to vision loss. Glia. 2020;: pubmed publisher
Wu X, Luo J, Liu H, Cui W, Guo K, Zhao L, et al. Recombinant Adiponectin Peptide Ameliorates Brain Injury Following Intracerebral Hemorrhage by Suppressing Astrocyte-Derived Inflammation via the Inhibition of Drp1-Mediated Mitochondrial Fission. Transl Stroke Res. 2020;11:924-939 pubmed publisher
Attia G, Elmansy R, Elsaed W. Neuroprotective effect of nilotinib on pentylenetetrazol-induced epilepsy in adult rat hippocampus: involvement of oxidative stress, autophagy, inflammation, and apoptosis. Folia Neuropathol. 2019;57:146-160 pubmed publisher
Coucha M, Shanab A, Sayed M, Vazdarjanova A, El Remessy A. Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Int J Mol Sci. 2019;20: pubmed publisher
Polyzos A, Lee D, Datta R, Hauser M, Budworth H, Holt A, et al. Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice. Cell Metab. 2019;29:1258-1273.e11 pubmed publisher
Ouyang J, Sun W, Xiao X, Li S, Jia X, Zhou L, et al. CPSF1 mutations are associated with early-onset high myopia and involved in retinal ganglion cell axon projection. Hum Mol Genet. 2019;28:1959-1970 pubmed publisher
van den Pol A, Mao G, Yang Y, Ornaghi S, Davis J. Zika Virus Targeting in the Developing Brain. J Neurosci. 2017;37:2161-2175 pubmed publisher
Hua Z, Emiliani F, Nathans J. Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems. Neural Dev. 2015;10:21 pubmed publisher
Eid M, El Kowrany S, Othman A, El Gendy D, Saied E. Immunopathological changes in the brain of immunosuppressed mice experimentally infected with Toxocara canis. Korean J Parasitol. 2015;53:51-8 pubmed publisher
product information
Product Type :
Antibody
Product Name :
GFAP Polyclonal Antibody
Catalog # :
PA5-16291
Quantity :
500 uL
Price :
US 562.00
Clonality :
Polyclonal
Purity :
purified
Host :
Rabbit
Reactivity :
Bovine, Chicken, Guinea Pig, Hamster, Human, Mouse, Non-human primate, Ovine, Rat
Applications :
Immunocytochemistry: 1:100-1:250, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 1:1,000
Species :
Bovine, Chicken, Guinea Pig, Hamster, Human, Mouse, Non-human primate, Ovine, Rat
Isotype :
IgG
Storage :
4 C
Description :
GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
Immunogen :
GFAP isolated from cow spinal cord
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:100-1:250, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 1:1,000
Aliases :
6330404F12Rik; 65 kDa glutamic acid decarboxylase; AI836096; ALXDRD; Astrocyte or Intermediate Filament Protein; cb345; class III intermediate filament protein; etID36982.3; FLJ45472; GAD(65); Gad2; Gad-2; GAD65; GAD-65; GFAP; GFAP epsilon; gfap protein; gfapl; glial fibrillary acidic protein; Glial Fibrillary Acidic Protein (GFAP); glial fibrillary acidic protein alpha; glutamate decarboxylase 2; Glutamate decarboxylase 65 kDa isoform; glutamic acid decarboxylase 2; I79_011607; intermediate filament; intermediate filament protein; intermediate filament protein; GFAP; Unknown (protein for MGC:139638); wu:fb34h11; wu:fk42c12; xx:af506734; zgc:110485; zGFAP; intermediate filament protein; zrf-1 antigen
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA