uPAR Polyclonal Antibody | Invitrogen PA5-15478 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

uPAR Polyclonal Antibody

catalog :

PA5-15478

quantity :

400 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:100	Owonikoko T, Zhang G, Kim H, Stinson R, Bechara R, Zhang C, et al. Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer. J Transl Med. 2016;14:111 pubmed publisher
	Gordian E, Welsh E, Gimbrone N, Siegel E, Shibata D, Creelan B, et al. Transforming growth factor β-induced epithelial-to-mesenchymal signature predicts metastasis-free survival in non-small cell lung cancer. Oncotarget. 2019;10:810-824 pubmed publisher

product information

Product Type :

Antibody

Product Name :

uPAR Polyclonal Antibody

Catalog # :

PA5-15478

Quantity :

400 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue. Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer. UPAR appears to be a useful prognostic marker for advanced endometrial cancer.

Immunogen :

KLH conjugated synthetic peptide between 136-166 amino acids from the central region of human PLAUR

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1,000

Aliases :

Cd87; MO3; Monocyte activation antigen Mo3; Par; plasminogen activator urokinase receptor 3; plasminogen activator, urokinase receptor; PLAUR; Plaur3; sCD87; soluble CD87; uPAR; U-PAR; uPAR-2; uPAR-3; u-plasminogen activator receptor form 2; urinary plasminogen activator receptor 2; urinary plasminogen activator receptor 3; URKR; urokinase plasminogen activator receptor; urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor; urokinase-type plasminogen activator receptor

more info or order :

Invitrogen product webpage