SEC16A Polyclonal Antibody | Invitrogen PA5-144561 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SEC16A Polyclonal Antibody

catalog :

PA5-144561

quantity :

100 uL

price :

US 353.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

Saccharomyces cerevisiae S288C

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

SEC16A Polyclonal Antibody

Catalog # :

PA5-144561

Quantity :

100 uL

Price :

US 353.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Yeast

Applications :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Species :

Yeast

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.

Immunogen :

Recombinant Saccharomyces cerevisiae (strain ATCC 204508/S288c) (Baker's yeast) SEC16 protein (280-430aa)

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: Assay-dependent

Aliases :

KIAA0310; p250; protein SEC16 homolog A; protein transport protein Sec16A; SEC16; SEC16 homolog A; SEC16 homolog A, endoplasmic reticulum export factor; SEC16A; SEC16L