Bi-1 Polyclonal Antibody | Invitrogen PA5-143940 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Bi-1 Polyclonal Antibody

catalog :

PA5-143940

quantity :

100 ug

price :

US 394.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Bi-1 Polyclonal Antibody

Catalog # :

PA5-143940

Quantity :

100 ug

Price :

US 394.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Paraffin): 2-5 ug/mL, Western Blot: 0.25-0.5 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C

Description :

BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, itis thought to involve regulation of Ca2+ handling by the ER.

Immunogen :

A synthetic peptide corresponding to a sequence of human BI-1/TMBIM6 (RKINFDALLKFSHITPSTQQHLK).

Format :

Lyophilized

Applications w/Dilutions :

Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Paraffin): 2-5 ug/mL, Western Blot: 0.25-0.5 ug/mL

Aliases :

5031406P05Rik; Ab1-011; Ac1-149; Bax inhibitor 1; Bax inhibitor-1; BAXI1; Bi1; BI-1; Cc1-27; Tegt; testis enhanced gene transcript; testis-enhanced gene transcript protein; Tmbim6; transmembrane BAX inhibitor motif containing 6; transmembrane BAX inhibitor motif-containing protein 6