TMPRSS2 Polyclonal Antibody | Invitrogen PA5-14264 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TMPRSS2 Polyclonal Antibody

catalog :

PA5-14264

quantity :

400 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 10

Reference
McQuaid C, Solorzano A, Dickerson I, Deane R. Uptake of severe acute respiratory syndrome coronavirus 2 spike protein mediated by angiotensin converting enzyme 2 and ganglioside in human cerebrovascular cells. Front Neurosci. 2023;17:1117845 pubmed publisher
Wettstein L, Knaff P, Kersten C, Muller P, Weil T, Conzelmann C, et al. Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture. Commun Biol. 2022;5:681 pubmed publisher
Zankharia U, Yadav A, Yi Y, Hahn B, Collman R. Highly restricted SARS-CoV-2 receptor expression and resistance to infection by primary human monocytes and monocyte-derived macrophages. J Leukoc Biol. 2022;112:569-576 pubmed publisher
Carter Timofte M, Arulanandam R, Kurmasheva N, Fu K, Laroche G, Taha Z, et al. Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern. ACS Infect Dis. 2021;7:3034-3051 pubmed publisher
Torices S, Cabrera R, Stangis M, Naranjo O, Fattakhov N, Téglás T, et al. Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection. J Neuroinflammation. 2021;18:167 pubmed publisher
Chen Y, Lear T, EVANKOVICH J, Larsen M, Lin B, Alfaras I, et al. A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry. Nat Commun. 2021;12:3907 pubmed publisher
Wettstein L, Weil T, Conzelmann C, Müller J, Groß R, Hirschenberger M, et al. Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection. Nat Commun. 2021;12:1726 pubmed publisher
Huerga Encabo H, Grey W, Garcia Albornoz M, WOOD H, Ulferts R, Aramburu I, et al. Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients. Stem Cell Reports. 2021;16:428-436 pubmed publisher
Vandergaast R, Carey T, Reiter S, Lech P, Gnanadurai C, Tesfay M, et al. Development and validation of IMMUNO-COV™: a high-throughput clinical assay for detecting antibodies that neutralize SARS-CoV-2. bioRxiv. 2020;: pubmed publisher
Zhou J, Li C, Liu X, Chiu M, Zhao X, Wang D, et al. Infection of bat and human intestinal organoids by SARS-CoV-2. Nat Med. 2020;26:1077-1083 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TMPRSS2 Polyclonal Antibody

Catalog # :

PA5-14264

Quantity :

400 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:10-1:50, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

TMPRSS2 is a protein that belongs to the serine protease family. The protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. Its gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage.

Immunogen :

KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TMPRSS2

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:10-1:50, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1,000

Aliases :

D16Ertd61e; EC 3.4.219; epitheliasin; FLJ41954; MGC6821; Plasmic transmembrane protein X; PP9284; PRSS10; Serine protease 10; Tmprss2; TMPS2; Transmembrane protease serine 2; Transmembrane protease serine 2 catalytic chain; Transmembrane protease serine 2 non-catalytic chain; transmembrane protease, serine 2