Nodal Polyclonal Antibody | Invitrogen PA5-142300 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Nodal Polyclonal Antibody

catalog :

PA5-142300

quantity :

100 ug

price :

US 444.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Nodal Polyclonal Antibody

Catalog # :

PA5-142300

Quantity :

100 ug

Price :

US 444.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Goat

Reactivity :

Human, Rat

Applications :

Immunohistochemistry (Paraffin): 3.75 ug/mL, Western Blot: 0.01-0.1 ug/mL

Species :

Human, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

NODAL is an important TGF-beta family protein in cellular differentiation. While constitutively expressed in many developing tissues, NODAL is problematically associated with the differentiation and development of many cancers. The expression of NODAL is regulated by a Notch signaling pathway, which when disrupted contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma. The abundance of NODAL expression in melanoma can help determine the stage of cancer and metastatic type/progression when tested in IHC. NODAL interactions with Cripto also predispose toward tumor progression. Overexpression of NODAL is also associated with preeclamptic placenta.

Immunogen :

Peptide with sequence DRSQLCRKVKFQ.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 3.75 ug/mL, Western Blot: 0.01-0.1 ug/mL

Aliases :

early embryo mesoderm formation; HTX5; MGC138230; Nodal; nodal growth differentiation factor; nodal homolog; Tg.413d; transgenic lethal 413.d