This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
JIP3 Polyclonal Antibody
catalog :
PA5-142058
quantity :
100 ug
price :
US 444.00
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
mouse
application :
immunohistochemistry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
JIP3 Polyclonal Antibody
Catalog # :
PA5-142058
Quantity :
100 ug
Price :
US 444.00
Clonality :
Polyclonal
Purity :
Ammonium sulfate precipitation
Host :
Goat
Reactivity :
Mouse
Applications :
Immunohistochemistry (Paraffin): 4-6 ug/mL
Species :
Mouse
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members, JNK2 and JNK3, have been identified. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.
Immunogen :
Peptide with sequence MEIQMDEGGGVV-C (aa 2-13).
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 4-6 ug/mL
Aliases :
BB120594; c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1; C-jun-amino-terminal kinase interacting protein 3; C-Jun-amino-terminal kinase-interacting protein 3; D17Wsu15e; homolog of Drosophila Sunday driver 2; JIP3; JIP-3; JNK MAP kinase scaffold protein 3; JNK/SAPK-associated protein 1; JNK/SAPK-associated protein 1c; JNK/SAPK-associated protein-1; JNK/stress-activated protein kinase-associated protein 1; JNK-interacting protein 3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; JUN/SAPK-associated protein 1; KIAA1066; MAPK8IP3; mitogen activated protein kinase 8 interacting protein 3; mitogen-activated protein kinase 8 interacting protein 3; mitogen-activated protein kinase 8-interacting protein 3; mKIAA1066; Sunday driver 2; syd; SYD2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA