PRKAR2B Polyclonal Antibody | Invitrogen PA5-13799 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PRKAR2B Polyclonal Antibody

catalog :

PA5-13799

quantity :

400 uL

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s2d western blot; rat; 1:1000; loading ...; fig s2a	Ye J, Yin Y, Liu H, Fang L, Tao X, Wei L, et al. Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation. Aging Cell. 2020;19:e13055 pubmed publisher
western blot; human; loading ...; fig s1a	Sha J, Xue W, Dong B, Pan J, Wu X, Li D, et al. PRKAR2B plays an oncogenic role in the castration-resistant prostate cancer. Oncotarget. 2017;8:6114-6129 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PRKAR2B Polyclonal Antibody

Catalog # :

PA5-13799

Quantity :

400 uL

Price :

US 454.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Western Blot: 1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.

Immunogen :

KLH conjugated synthetic peptide between 32-62 amino acids from the N-terminal region of human PKA 2 beta (PRKAR2B)

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

AI451071; AW061005; cAMP-dependent protein kinase RII-beta regulatory subunit; cAMP-dependent protein kinase type II-beta regulatory chain; cAMP-dependent protein kinase type II-beta regulatory subunit; H_RG363E19.2; Pkarb2; PKARIIbeta; PRKAR2; PRKAR2B; protein kinase cAMP-dependent type II regulatory subunit beta; protein kinase, cAMP dependent regulatory, type II beta; protein kinase, cAMP-dependent, regulatory subunit type II beta; protein kinase, cAMP-dependent, regulatory, type II, beta; RATDNA; RII(beta); RII-BETA; Type II beta regulatory subunit of cAMP-dependent protein kinase; WUGSC:H_RG363E19.2

more info or order :

Invitrogen product webpage