CRY1 Polyclonal Antibody | Invitrogen PA5-13124 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CRY1 Polyclonal Antibody

catalog :

PA5-13124

quantity :

400 uL

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; rat; loading ...; fig 4c	Barca Mayo O, Pons Espinal M, Follert P, Armirotti A, Berdondini L, De Pietri Tonelli D. Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling. Nat Commun. 2017;8:14336 pubmed publisher
	Janjić K, Kurzmann C, Moritz A, Agis H. Core circadian clock gene expression in human dental pulp-derived cells in response to L-mimosine, hypoxia and echinomycin. Eur J Oral Sci. 2018;126:263-271 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CRY1 Polyclonal Antibody

Catalog # :

PA5-13124

Quantity :

400 uL

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Various biochemical, physiological and behavioral processes display circadian rhythms controlled by an internal biological clock. The central 'gears' driving this clock appear to be composed of an autoregulatory transcription/post translation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.

Immunogen :

KLH conjugated synthetic peptide between 556-586 amino acids from the C-terminal region of human Cry1

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1,000

Aliases :

AU020726; AU021000; Cry1; cryptochrome 1 (photolyase-like); cryptochrome circadian clock 1; cryptochrome-1; PHLL1

more info or order :

Invitrogen product webpage