This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
alpha Actinin 4 Polyclonal Antibody
catalog :
PA5-117766
quantity :
100 uL
price :
US 434.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
alpha Actinin 4 Polyclonal Antibody
Catalog # :
PA5-117766
Quantity :
100 uL
Price :
US 434.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography, Protein A
Host :
Rabbit
Reactivity :
Human
Applications :
Immunohistochemistry (Paraffin): 1:500-1:2,000, Immunoprecipitation: 1-5 uL/mg of lysate, Western Blot: 1:500-1:2,000
Species :
Human
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Immunogen :
E. coli-derived Human alpha Actinin 4/ACTN4 fragment
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 1:500-1:2,000, Immunoprecipitation: 1-5 uL/mg of lysate, Western Blot: 1:500-1:2,000
Aliases :
actinin alpha 4; ACTININ-4; actinin-Alpha-4; Actn4; alpha actinin 4; alpha-actinin-4; C77391; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; FSGS; FSGS1; non-muscle alpha-actinin 4
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA