Phospho-JAK2 (Tyr1007, Tyr1008) Polyclonal Antibody | Invitrogen PA5-117229 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-JAK2 (Tyr1007, Tyr1008) Polyclonal Antibody

catalog :

PA5-117229

quantity :

100 uL

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

Phospho-JAK2 (Tyr1007, Tyr1008) Polyclonal Antibody

Catalog # :

PA5-117229

Quantity :

100 uL

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

ELISA: 1 ug/mL, Western Blot: 1:500-1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.

Immunogen :

A synthetic phosphorylated peptide around Y1007 of human JAK2 (NP_0049631)

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Western Blot: 1:500-1:1,000

Aliases :

EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2